Open AccessJournal Article
lncRNA MEG3 inhibit proliferation and metastasis of gastric cancer via p53 signaling pathway.
TLDR
It is found that overexpression of lncRNA MEG3 could decrease the proliferation and metastasis of gastric cancer cells and could also increase the expression of p53.Abstract:
Objective lncRNA MEG3 has been reported as a tumor suppressor gene in many different kinds of cancer, but its role in gastric cancer has not been fully understood. Then, we would like to explore its mechanism in gastric cancer. Patients and methods We first used qRT-PCR to detect the expression of lncRNA MEG3, then CCK8 and wound healing assay were used to detect the effect of lncRNA MEG3 on gastric cancer cells. Western blot assay was used to measure the expression of p53 when lncRNA MEG3 was overexpressed. Results lncRNA MEG3 was highly expressed in the adjacent tissue, compared to the one in gastric cancer tissue. What's more, we also found that overexpression of lncRNA MEG3 could decrease the proliferation and metastasis of gastric cancer cells. Finally, overexpression of lncRNA MEG3 could also increase the expression of p53. Conclusions lncRNA MEG3 could inhibit the proliferation and metastasis of gastric cancer.read more
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Identification of a robust signature for clinical outcomes and immunotherapy response in gastric cancer: based on N6-methyladenosine related long noncoding RNAs
TL;DR: Wang et al. as mentioned in this paper constructed a m6A-related lncRNA prognostic signature to evaluate both status and prognosis of the disease and validated the latent regulative mechanism of m6a-related LncRNA in GC cell lines.
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LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study
Yi Zheng,Yi Zheng,Meng Wang,Shuqian Wang,Peng Xu,Yujiao Deng,Yujiao Deng,Shuai Lin,Na Li,Na Li,Kang Liu,Yuyao Zhu,Yuyao Zhu,Zhen Zhai,Zhen Zhai,Ying Wu,Ying Wu,Zhijun Dai,Zhijun Dai,Gaixia Zhu +19 more
TL;DR: Structural prediction based on RNAfold found rs3087918 may influence the secondary structure of MEG3 and indicate that mEG3 haplotype TCG may increase the risk of breast cancer.
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Comprehensive Analysis of the Expression Profiles of Long Non-Coding RNAs with Associated ceRNA Network Involved in the Colon Cancer Staging and Progression
Meini Wu,Wenliang Li,Fengchang Huang,Jing Sun,Kang ping Li,Jiandong Shi,Jingyu Yang,Li Jianfang,Li Yanhan,Ningzhu Hu,Yunzhang Hu +10 more
TL;DR: Analysis of lncRNAs and their ceRNA networks associated with colon cancer suggested that lncRNA CDKN2B-AS1, MIR4435-2HG, and MEG3 may act as diagnostic biomarkers for the development of CC.
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lncRNA MEG3 Downregulation Relieves Intracerebral Hemorrhage by Inhibiting Oxidative Stress and Inflammation in an miR-181b-Dependent Manner.
TL;DR: MEG3-shRNA restrained oxidative stress and inflammation following ICH in an miR-181b-dependent manner and inhibited inflammatory cytokines release and reduced oxidative stress.
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lncRNA MCM3AP-AS1 inhibits the progression of colorectal cancer via the miR-19a-3p/FOXF2 axis.
TL;DR: In this article, the relative expression of MCM3AP-AS1, miR-19a-3p and forkhead box F2 (FOXF2) mRNA in 53 cases of colorectal cancer and its adjacent normal tissues, human normal colonic mucosal cells (FHC cells) and CRC cell lines was examined by a quantitative real-time polymerase chain reaction, and the changes of cell multiplication and migration were examined by the cell counting kit-8 method, EdU test, and scratch-healing test, respectively.