Long-term Management of Panuveitis and Iris Heterochromia in an Ebola Survivor
Jessica G. Shantha,Ian Crozier,Jay B. Varkey,Colleen S. Kraft,G. Marshall Lyon,Aneesh K. Mehta,Renee Donahue Carlson,Charles E. Hill,Gokul Kumar,Matthew R. Debiec,Purnima Patel,Timothy W. Olsen,Robert B. Nussenblatt,Daniel F. Martin,Ute Ströher,Timothy M. Uyeki,Bruce S. Ribner,Justine R. Smith,Steven Yeh +18 more
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This article is published in Ophthalmology.The article was published on 2016-12-01 and is currently open access. It has received 23 citations till now. The article focuses on the topics: Panuveitis.read more
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Ebola virus disease: An emerging and re-emerging viral threat
Manuel Rojas,Diana M. Monsalve,Yovana Pacheco,Yeny Acosta-Ampudia,Carolina Ramírez-Santana,Aftab A Ansari,M. Eric Gershwin,Juan-Manuel Anaya +7 more
TL;DR: The molecular biology, pathogenesis, clinical manifestations, and treatment of Ebola virus disease are reviewed and some strategies for control of disease are discussed.
Journal ArticleDOI
Insights from clinical research completed during the west Africa Ebola virus disease epidemic.
TL;DR: New insights from patient-oriented research completed during the west Africa epidemic are discussed, ongoing knowledge gaps are identified, and priorities for future research are suggested.
Journal ArticleDOI
Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye.
Justine R. Smith,Shawn Todd,Liam M. Ashander,Theodosia Charitou,Theodosia Charitou,Yuefang Ma,Steven Yeh,Ian Crozier,Michael Michael,Binoy Appukuttan,Keryn A. Williams,David J. Lynn,David J. Lynn,Glenn A. Marsh +13 more
TL;DR: This bedside-to-bench research links ophthalmic findings in survivors of EVD who suffer from uveitis with interactions between retinal pigment epithelial cells and EBOV, and the molecular response of infected cells may contribute to the persistence of live E BOV within the human eye.
Journal ArticleDOI
Ebola virus – epidemiology, diagnosis, and control: threat to humans, lessons learnt, and preparedness plans – an update on its 40 year's journey
Raj Kumar Singh,Kuldeep Dhama,Yashpal Singh Malik,Muthannan Andavar Ramakrishnan,Kumaragurubaran Karthik,Rekha Khandia,Ruchi Tiwari,Ashok Munjal,Mani Saminathan,Swati Sachan,P. A. Desingu,Jobin Jose Kattoor,Hafiz M.N. Iqbal,Sunil K. Joshi +13 more
TL;DR: The current scenario of EBOV is discussed giving due emphasis on animal and veterinary perspectives along with advances in diagnosis and control strategies to be adopted, lessons learned from the recent outbreaks and the global preparedness plans.
Journal ArticleDOI
Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016
Paul J. Steptoe,Janet T Scott,Julia M. Baxter,Craig K. Parkes,Rahul Dwivedi,Gabriela Czanner,Matthew J. Vandy,Fayiah Momorie,Alimamy D Fornah,Patrick Komba,Jade Richards,Foday Sahr,Nicholas A. V. Beare,Malcolm G Semple +13 more
TL;DR: A lesion specific to Ebola virus disease showed an anatomical distribution suggesting neuronal transmission, and the distribution suggested neuronal transmission was driven by Ebola virus infection.
References
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Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
TL;DR: Evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo, and suggests that it is a candidate for treatment of Ebola hemorrhagic fever.
Journal ArticleDOI
Persistence of Ebola Virus in Ocular Fluid during Convalescence
Jay B. Varkey,Jessica G. Shantha,Ian Crozier,Colleen S. Kraft,G. Marshall Lyon,Aneesh K. Mehta,Gokul Kumar,Justine R. Smith,Markus H Kainulainen,Shannon L.M. Whitmer,Ute Ströher,Timothy M. Uyeki,Bruce S. Ribner,Steven Yeh +13 more
TL;DR: A patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence is described.
Journal ArticleDOI
The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
Colleen S. Kraft,Angela L. Hewlett,Scott A. Koepsell,Anne M. Winkler,Christopher J. Kratochvil,LuAnn Larson,Jay B. Varkey,Aneesh K. Mehta,G. Marshall Lyon,Rachel J. Friedman-Moraco,Vincent C. Marconi,Charles E. Hill,James N. Sullivan,Daniel W. Johnson,Steven J. Lisco,Mark J. Mulligan,Timothy M. Uyeki,Anita K. McElroy,Tara K. Sealy,Shelley Campbell,Christina F. Spiropoulou,Ute Ströher,Ian Crozier,Richard Sacra,Michael J. Connor,Viranuj Sueblinvong,Harold A. Franch,Philip W. Smith,Bruce S. Ribner,Philip W. Smith,Angela L. Hewlett,Shelly Schwedhelm,Kate Boulter,Elizabeth L. Beam,Shawn G. Gibbs,John J. Lowe,Christopher J. Kratochvil,James Sullivan,Daniel R Johnson,Steve Lisco,Craig A. Piquette,Kristina L. Bailey,Joseph Auxier,Brian Boer,Travis Hanson,Julia Kaseman,M. Salman Khan,Ji Hyun Rhee,Adam Wells,Diana F. Florescu,Andre C. Kalil,Mark E. Rupp,Valerie Becker,Bridget Boeckman,Erica Elder,Abby Fitch,Elizabeth Flood,Meagan Freml,Roman Frigge,Kelly Ann Hanzlik,Lois Jensen,Nicole Kraus,Drew Molacek,Jerry Nevins,Alicia Parker,Jeff Peters,Cheryl Rand,Karen Roesler,Kendall Ryalls,Morgan Shradar,Amanda Strain,Timothy Sunderman,Jennifer Sundermeier,John Swanhorst,Angela Vasa,Jean Bellinghausen,Frank Freihaut,Susan Denny,Lauren Mainelli,Dee Pinkney,Deborah Ray,Jay Jevne,Kalen Knight,Derrick McCroy,Ralph Nadeau,Anna Nightser,Pete Iwen,Tony Sambol,Vicki L. Herrera,David Morgan,Sarah Trotter,Amy Kerby,Sue Peters,Timothy Southern,Caitlin N. Murphy,Rosanna Morris,Sue Nuss,Theresa Franco,Connie Ogden,Julie Lazure,Dawn Straub,Steve Hinrichs,Troy J. Plumb,Marius C. Florescu,John Becker,Jenna Souchek,Jon Beck,Peggy Heires,Bruce Geoffrey Gordon,Gail Paulsen,Barb Wolford,Jill Petersen,Nedra Marion,Kim Hayes,Kate Tyner,Taylor Wilson,Paul Baltes,Jenny Nowatzke,Jonathan Nguyen,Paul Turner,Barb Boonstra,Katelyn C. Jelden,Randy Portrey,Doug Stringfield,Bryan Scofield,Gary Svanda,Jolene Horihan,Chris Dahl,Megan Bruno,Kelsey Malm,Ron Litz,Jessica Fehringer,Katie D. Paladino,Tammy Opp,Sonia Bell,Anne Adams,Mary Beth Allen,Robert Bachman,William A. Bornstein,Dee Cantrell,Pam Cosper,Nancye Feistritzer,John P. Fox,Bryce Gartland,Jen Goodman,Susan Grant,Dallis Howard-Crow,Ira R Horowitz,David Pugh,Chad W.M. Ritenour,Toni Ash,Christopher Barnes,Jason H. Calhoun,Lauren Chapman,Tracey Daye,Haley Durr,Shunasee Evans,Janice Gentry,Jan Ginnane,Chris Haynes,Carolyn Hill,Dustin Hillis,Crystal Johnson,Jessica Loomis,Josia Mamora,Laura Mitchell,Jill S. Morgan,Nancy Osakwe,Jacqueline Owen,Sarah Piazza,Kristina Shirley,Jodi Siddens,Carrie Silas,Jason Slabach,Elaina Tirador,Donnette Todd,Sharon Vanairsdale,Nicole Brammer,Juli Buchanan,Eileen M. Burd,John Cardella,Brenda Eaves,Crystal Evans,Krista Hostetler,Karen Jenkins,Maureen Lindsey,Jordan Magee,Randall Powers,James C. Ritchie,Emily L. Ryan,Shannon Bonds,Amir Emamifar,Tish Kuban,Jan Pack,Susan Rogers,George Golston,Sean Kaufman,Patricia Olinger,Sean Olinger,Kalpana Rengarajan,Scott Thomaston,Emily Beck,Paula Desroches,Cynthia Hall,Celeste Walker,Connie Bryant,Betsy O. Hackman,Regina Howard,Marolyn Jones,Jeff Broughton,Brian Frisle,Robert H. Jackson,Jerry Lewis,Robin Brown-Haithco,Miranda Lynn Gartin,Erica Geralds-Washington,Rhonda James-Jones,Donald Miller,Dan Stark,Gentrice McGee,Porcia Jones,Linda Scott-Harris,James Cain,Roderick Davis,Tyrone Johnson,Tyrone Pickett,Anthony Shaw,Tenina Truesdale,Jim Blum,Laureen Hill,Jon Sevransky,Joel Zivot,Seth Walker,Matthew A. Klopman,Ricky Matkins,Cathy Meechan,Paul Meechan,Kathy Schwock,Jen Schuck,Kathy Stack,Francis Wolf,Bruce Bray,Alexander P. Isakov,Sam Shartar,Wade Miles,Aaro Jamison,John Arevalo,Gail Stallings,Janet Christenbury,Vince Dollard,Melanie De Gennaro,Holly Korschun,Nancy Seideman,Tom Ziegler,Daniel P. Griffith,Nisha J. Dave,Susan Wall,Melida Hall,Dwania McGhee,Tim Clarke,Rachel Vaught,Katrina Peterson-Pileri +261 more
TL;DR: While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.
Journal ArticleDOI
Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study.
John G. Mattia,Mathew J Vandy,Joyce Chang,Devin Platt,Kerry Dierberg,Daniel G. Bausch,Tim Brooks,Sampha Conteh,Ian Crozier,Ian Crozier,Robert A. Fowler,Robert A. Fowler,Amadu Kamara,Cindy Kang,Srividya Mahadevan,Yealie Mansaray,Lauren Marcell,Gillian McKay,Tim O'Dempsey,Tim O'Dempsey,Victoria Parris,Ruxandra Pinto,Audrey Rangel,Alex P. Salam,Jessica G. Shantha,Vanessa Wolfman,Steven Yeh,Adrienne K. Chan,Adrienne K. Chan,Adrienne K. Chan,Sharmistha Mishra,Sharmistha Mishra +31 more
TL;DR: The findings underscore the need for early clinical follow-up of survivors of EVD and urgent provision of ocular care as part of health systems strengthening in EVD-affected west African countries.
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Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study.
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Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors — Final Report
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