Longevity and cost of implantable intrathecal drug delivery systems for chronic pain management: A retrospective analysis of 365 patients
Robert Bolash,Belinda L. Udeh,Youssef Saweris,Maged Guirguis,Jarrod E. Dalton,Natalya Makarova,Nagy Mekhail +6 more
TLDR
Continuous intrathecal administration of opioids results in higher subarachnoid drug concentrations, improved pain scores, and less frequent side effects when compared with systemic opioid administration.Abstract:
Objectives
Intrathecal drug delivery systems represent an important component of interventional strategies for refractory chronic pain syndromes. Continuous intrathecal administration of opioids results in higher subarachnoid drug concentrations, improved pain scores, and less frequent side effects when compared with systemic opioid administration. Substantial costs arise at the time of surgical implantation and at revision for battery depletion or treatment of a complication. Despite current widespread use, the real-world longevity and cost of implanted intrathecal pumps (ITP) has not been fully quantified.read more
Citations
More filters
Journal ArticleDOI
Cerebrospinal Fluid Mechanics and Its Coupling to Cerebrovascular Dynamics
TL;DR: An overview of the current knowledge of pulsatile CSF motion is provided and open questions regarding CSF dynamics as they relate to the understanding and management of diseases are addressed.
Journal ArticleDOI
Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases.
Fernanda P. Pons-Faudoa,Fernanda P. Pons-Faudoa,Andrea Ballerini,Andrea Ballerini,Jason Sakamoto,Alessandro Grattoni +5 more
TL;DR: This review discusses implantable drug delivery technologies in an advanced stage of development or in clinical use and focuses on the state-of-the-art of reservoir-based implants including pumps, electromechanical systems, and polymers, sites of implantation and side effects, and deployment in developing countries.
Journal ArticleDOI
Zero-order drug delivery: State of the art and future prospects.
TL;DR: Zero-order drug delivery systems have the potential to overcome the issues facing immediate-release and first-order systems by releasing drug at a constant rate, thereby maintaining drug concentrations within the therapeutic window for an extended period of time.
Journal ArticleDOI
Multicenter Retrospective Study of Neurostimulation With Exit of Therapy by Explant
Jason E. Pope,Timothy R. Deer,Steven M. Falowski,David A. Provenzano,Michael Hanes,Salim M. Hayek,Jacob Amrani,Jonathan D. Carlson,Ioannis Skaribas,Kris Parchuri,W. Porter McRoberts,Robert Bolash,Nameer Haider,Maged Hamza,Kasra Amirdelfan,Sean Graham,Corey W. Hunter,Eric T. Lee,Sean Li,Michael Yang,Lucas W. Campos,Shrif Costandi,Robert Levy,Nagy Mekhail +23 more
TL;DR: This work is interested in exploring the patient characteristics of those patients who have the SCS device explanted and how the device affects their quality of life.
Journal ArticleDOI
The Polyanalgesic Consensus Conference (PACC): Recommendations for Trialing of Intrathecal Drug Delivery Infusion Therapy.
Timothy R. Deer,Salim M. Hayek,Jason E. Pope,Tim J. Lamer,Maged Hamza,Jay S. Grider,Steven M. Rosen,Samir Narouze,Christophe Perruchoud,Simon Thomson,Marc Russo,Eric Grigsby,Daniel M. Doleys,Marilyn S. Jacobs,Michael Saulino,Paul J. Christo,Philip Kim,Philip Kim,Elliot Marc Huntoon,Elliot S. Krames,Nagy Mekhail +20 more
TL;DR: A consensus on best practices for determining appropriate use of IT drug infusion may involve testing/trialing this therapy before implantation.
References
More filters
Book
An introduction to the bootstrap
Bradley Efron,Robert Tibshirani +1 more
TL;DR: This article presents bootstrap methods for estimation, using simple arguments, with Minitab macros for implementing these methods, as well as some examples of how these methods could be used for estimation purposes.
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal ArticleDOI
An Introduction to the Bootstrap.
Journal ArticleDOI
Opioid complications and side effects.
Ramsin M Benyamin,Andrea M. Trescot,Sukdeb Datta,Ricardo M. Buenaventura,Rajive Adlaka,Nalini Sehgal,Scott E. Glaser,Ricardo Vallejo +7 more
TL;DR: The role of opioids in the treatment of chronic pain is influenced by the fact that these potent analgesics are associated with a significant number of side effects and complications, and these phenomena are the focus of this review.