Journal ArticleDOI
Low-temperature Argon plasma - a new strategy against multiresistance of germs and impaired wound healing
Georg Isbary,Wilhelm Stolz,Tetsuji Shimizu,Bernd Steffes,Tetyana Nosenko,Julia L. Zimmermann,René Pompl,Wolfram Bunk,Hans-Ulrich Schmidt,Shuitsu Fujii,Gregor E. Morfill +10 more
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This article is published in Free Radical Biology and Medicine.The article was published on 2009-01-01. It has received 8 citations till now.read more
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Journal ArticleDOI
Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential
TL;DR: A comprehensive overview of the chemical properties and some in vivo effects observed with various classes of compounds with a special emphasis on porphyrin-based compounds is provided.
Journal ArticleDOI
Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.
Ines Batinic-Haberle,Ivan Spasojevic,Hubert M. Tse,Artak Tovmasyan,Zrinka Rajić,Daret K. St. Clair,Zeljko Vujaskovic,Mark W. Dewhirst,Jon D. Piganelli +8 more
TL;DR: The most efficacious Mn(III) porphyrinic scavengers of reactive species have positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic facilitation for the reaction with negatively charged species such as O2•− and ONOO− and the pro-oxidative action of MnPs in suppressing NF-κB activation in nucleus has been substantiated.
Journal ArticleDOI
Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.
Xiaodong Ye,Diane Renee Fels,Artak Tovmasyan,Katherine M. Aird,Casey Dedeugd,Jennifer L. Allensworth,Ivan Kos,Won Park,Ivan Spasojevic,Gayathri R. Devi,Mark W. Dewhirst,Kam W. Leong,Ines Batinic-Haberle +12 more
TL;DR: Two ortho isomers of Mn(III)N-alkylpyridylporphyrins, MnTE-2-PyP5+ and MnTnHex-3- PyP5+, which differ greatly with regard to their metal-centered reduction potential, E1/2 (MnIIIP/Mn IIP) and lipophilicity, were explored and the trend towards tumour growth suppression was detected.
Journal ArticleDOI
Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N -methoxyalkylpyridylporphyrins
Artak Tovmasyan,Zrinka Rajić,Ivan Spasojevic,Júlio S. Rebouças,Xin Chen,Daniela Salvemini,Huaxin Sheng,David S. Warner,Ludmil Benov,Ines Batinic-Haberle +9 more
TL;DR: This work modified the alkyl chains of the lipophilic meta compound, MnTnHex-3-PyP(5+) via introduction of a methoxy group, to diminish its toxicity (and/or enhance its efficacy), while maintaining high SOD-like activity and lipophilicity.
Journal ArticleDOI
Inhibition of inflammatory reactions in 2,4-Dinitrochlorobenzene induced Nc/Nga atopic dermatitis mice by non-thermal plasma
TL;DR: It is revealed that NTP significantly inhibits several immune reactions of AD by regulating NF-κB activity, which could be useful to suppress the exaggerated immune reactions in severe skin inflammatory diseases such as AD.