Journal ArticleDOI
Lung function in early adulthood and health in later life: a transgenerational cohort analysis
TLDR
Low peak lung function in early adulthood is common in the general population and could identify a group of individuals at risk of early comorbidities and premature death.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2017-12-01. It has received 206 citations till now. The article focuses on the topics: Cohort & Cohort study.read more
Citations
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Journal ArticleDOI
Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life
Dinh S Bui,Dinh S Bui,Caroline J Lodge,John Burgess,Adrian J. Lowe,Jennifer L. Perret,Minh Bui,Gayan Bowatte,Gayan Bowatte,Lyle C. Gurrin,David P Johns,Bruce Thompson,Garun S. Hamilton,Peter Frith,Alan L. James,Paul S. Thomas,Deborah Jarvis,Deborah Jarvis,Cecilie Svanes,Cecilie Svanes,Melissa Russell,Stephen Morrison,Stephen Morrison,Iain Feather,Katrina J. Allen,Richard Wood-Baker,John L. Hopper,Graham G. Giles,Michael J. Abramson,Eugene Haydn Walters,Eugene Haydn Walters,Melanie C. Matheson,Shyamali C. Dharmage +32 more
TL;DR: It is postulate that reducing maternal smoking, encouraging immunisation, and avoiding personal smoking, especially in those with smoking parents or low childhood lung function, might minimise COPD risk.
Journal ArticleDOI
Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease
Alvar Agusti,James C Hogg +1 more
TL;DR: The current understanding of the biology, diagnosis, and treatment of chronic obstructive pulmonary disease is examined in a pair of review articles.
Journal ArticleDOI
Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies
Danielle Belgrave,Raquel Granell,Steve Turner,John A. Curtin,Iain Buchan,Peter N. Le Souëf,Angela Simpson,A. John Henderson,Adnan Custovic +8 more
TL;DR: Reduction of childhood smoke exposure and minimisation of the risk of early-life sensitisation and wheezing exacerbations might reduce therisk of diminished lung function in early adulthood.
Journal ArticleDOI
Lung function trajectories in health and disease.
Alvar Agusti,Rosa Faner +1 more
TL;DR: Evidence shows that several lung function trajectories exist throughout the life course and, importantly, that some of them are associated with substantial implications for health and disease.
Journal ArticleDOI
Defining the relationship between COPD and CVD: what are the implications for clinical practice?
TL;DR: Evidence indicates that the increased risks for CVD are particularly pronounced in COPD patients in mid-to-late-middle-age and thus it is in this age group that the benefits of early intervention may prove to be the most effective.
References
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Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations
Philip H. Quanjer,Sanja Stanojevic,Tim J Cole,Xaver Baur,Graham L. Hall,Bruce H. Culver,Paul L. Enright,John L. Hankinson,Mary S.M. Ip,Jinping Zheng,Janet Stocks +10 more
TL;DR: Spirometric prediction equations for the 3–95-age range are now available that include appropriate age-dependent lower limits of normal for spirometric indices, which can be applied globally to different ethnic groups.
Journal ArticleDOI
Spirometric Reference Values from a Sample of the General U.S. Population
TL;DR: Hankinson and Odencrantz as mentioned in this paper used a piecewise polynomial model with age and height as predictors to derive reference values for three race/ethnic groups and should prove useful for diagnostic and research purposes.
Journal ArticleDOI
Cox's Regression Model for Counting Processes: A Large Sample Study
TL;DR: In this article, the Cox regression model for censored survival data is extended to a model where covariate processes have a proportional effect on the intensity process of a multivariate counting process, allowing for complicated censoring patterns and time dependent covariates.
Journal ArticleDOI
Orchestrating high-throughput genomic analysis with Bioconductor
Wolfgang Huber,Vincent J. Carey,Robert Gentleman,Simon Anders,Marc R. J. Carlson,Benilton S. Carvalho,Héctor Corrada Bravo,Sean Davis,Laurent Gatto,Thomas Girke,Raphael Gottardo,Florian Hahne,Kasper D. Hansen,Rafael A. Irizarry,Michael S. Lawrence,Michael I. Love,James W. MacDonald,Valerie Obenchain,Andrzej K. Oleś,Hervé Pagès,Alejandro Reyes,Paul Shannon,Gordon K. Smyth,Dan Tenenbaum,Levi Waldron,Martin Morgan +25 more
TL;DR: An overview of Bioconductor, an open-source, open-development software project for the analysis and comprehension of high-throughput data in genomics and molecular biology, which comprises 934 interoperable packages contributed by a large, diverse community of scientists.
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Peter Lange,Bartolome R. Celli,Alvar Agusti,Gorm B. Jensen,Miguel Divo,Rosa Faner,Stefano Guerra,Jacob Louis Marott,Fernando D. Martinez,Pablo Martínez-Camblor,Paula Meek,Caroline A. Owen,Hans Petersen,Victor Pinto-Plata,Peter Schnohr,Akshay Sood,Joan B. Soriano,Yohannes Tesfaigzi,Jørgen Vestbo +18 more