Malignant vascular tumours of the pleura in “asbestos” workers and endothelial differentiation in malignant mesothelioma
Richard Attanoos,S K Suvarna,E Rhead,M Stephens,T J Locke,M N Sheppard,Frederick D. Pooley,Allen R. Gibbs +7 more
TLDR
Endothelial differentiation does not appear to occur in mesothelioma and therefore should be clearly separated from it, and no definite association between pleural epithelioid haemangioendothelIoma and exposure to asbestos can be made from this small series of cases.Abstract:
BACKGROUND Three cases of diffuse malignant vascular tumours of the pleura are described which mimicked malignant mesothelioma clinically and pathologically (so called “pseudomesothelioma”). All had occupational histories of exposure to asbestos. The relationship of these tumours to mesothelioma and asbestos exposure is discussed. METHODS To examine the histogenetic relationship between mesothelioma and these three tumours an immunohistochemical analysis of vascular marker (CD31, CD34, and Von Willebrand factor) expression was undertaken in 92 cases of pleural mesothelioma, in addition to these three tumours. Electron microscopic fibre analysis of lung tissue was performed on each of the three cases to assess asbestos fibre content. RESULTS Diffuse pleural epithelioid haemangioendotheliomas may closely resemble malignant mesothelioma clinically and pathologically but, of the 92 pleural mesotheliomas tested, none showed expression of CD31, CD34, and Von Willebrand factor. Although all three cases had claimed exposure to asbestos, ferruginous bodies typical of asbestos were only seen by light microscopy in case 2, and only in this subject was the asbestos fibre content raised in comparison with the range seen in a non-exposed background population. The latent period in the pleural epithelioid haemangioendotheliomas ranged from 18 to 60 years. CONCLUSIONS Endothelial differentiation does not appear to occur in mesothelioma and therefore should be clearly separated from it. No definite association between pleural epithelioid haemangioendothelioma and exposure to asbestos can be made from this small series but further investigation is warranted.read more
Citations
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Angiogenesis is an independent prognostic factor in malignant mesothelioma.
John G. Edwards,John G. Edwards,Gerard Cox,Gerard Cox,A. Andi,J. L. Jones,Rosemary A. Walker,David A. Waller,Kenneth J. O'Byrne +8 more
TL;DR: In this article, the clinical relevance of angiogenesis, as assessed by microvessel density (MVD), is unclear in malignant mesothelioma (MM), and a stepwise multivariate Cox model was used to compare MVD with known prognostic factors and the EORTC and CALGB prognostic scoring systems.
Journal ArticleDOI
‘Pseudomesotheliomatous’ carcinomas of the pleura: a 10‐year analysis of cases from the Environmental Lung Disease Research Group, Cardiff
Richard Attanoos,Allen R. Gibbs +1 more
TL;DR: To undertake a clinicopathological study of diffuse serosal neoplasms of epithelial histogenesis which clinically and pathologically mimic malignant pleural mesothelioma.
Journal ArticleDOI
Problems in mesothelioma diagnosis.
Bruce Addis,Heather Roche +1 more
TL;DR: A review of some of the less common variants of mesothelioma and other pleural‐based tumours that enter into the differential diagnosis and addresses the uses and limitations of immunohistochemistry in different situations.
Journal ArticleDOI
Malignant mesothelioma with heterologous elements: clinicopathological correlation of 27 cases and literature review.
TL;DR: A diagnosis of heterologous mesothelioma should be made in preference to a diagnosis of primary pleural osteosarcoma or chondrosarcomas, regardless of cytokeratin positivity, as for conventional non-heterologous sarcomatoid mesot helioma.
Journal ArticleDOI
Mesothelioma with rhabdoid features: an ultrastructural and immunohistochemical study of 10 cases
TL;DR: It is important for pathologists to be aware that mesotheliomas can present rhabdoid features, not only because they can be confused with other malignancies that can exhibit a similar morphology, but also because of their apparently unusually aggressive behavior.
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