Manganese superoxide dismutase Ala-9Val polymorphism and risk of breast cancer in a population-based case–control study of African Americans and whites
Robert C. Millikan,Jon Player,Allan René de Cotret,Patricia G. Moorman,Gary S. Pittman,Vani Vannappagari,Chiu Kit J. Tse,Temitope O. Keku +7 more
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TLDR
The MnSOD genotype may contribute to an increased risk of breast cancer in the presence of specific environmental exposures and provide further evidence for the importance of reactive oxygen species and of oxidative DNA damage in the etiology of Breast cancer.Abstract:
A polymorphism in the manganese superoxide dismutase (MnSOD) gene, Ala-9Val, has been examined in association with breast cancer risk in several epidemiologic studies. Results suggest that the Ala allele increases the risk of breast cancer and modifies the effects of environmental exposures that produce oxidative damage to DNA. We examined the role of the MnSOD Ala-9Val polymorphism in a population-based case–control study of invasive and in situ breast cancer in North Carolina. Genotypes were evaluated for 2025 cases (760 African Americans and 1265 whites) and for 1812 controls (677 African Americans and 1135 whites). The odds ratio for MnSOD Ala/Ala versus any MnSOD Val genotypes was not elevated in African Americans (odds ratio = 0.9, 95% confidence interval = 0.7–1.2) or in whites (odds ratio = 1.0, 95% confidence interval = 0.8–1.2). Greater than additive joint effects were observed for the Ala/Ala genotype and smoking, radiation to the chest, and occupational exposure to ionizing radiation. Antagonism was observed between the Ala/Ala genotype and the use of nonsteroidal anti-inflammatory drugs. The MnSOD genotype may contribute to an increased risk of breast cancer in the presence of specific environmental exposures. These results provide further evidence for the importance of reactive oxygen species and of oxidative DNA damage in the etiology of breast cancer.read more
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Trends in oxidative aging theories
Florian L. Muller,Michael S. Lustgarten,Youngmok C. Jang,Arlan Richardson,Arlan Richardson,Holly Van Remmen,Holly Van Remmen +6 more
TL;DR: It is argued that a tentative case for oxidative stress as a life-span determinant can be made in Drosophila melanogaster, and where the free radical theory is headed is discussed, specifically, telomere/cell senescence, genomic instability, and the mitochondrial hypothesis of aging.
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Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women.
TL;DR: Novel epidemiologic evidence is provided that the mtDNA 10398A allele influences breast cancer susceptibility in African-American women and underappreciated factors in breast carcinogenesis are identified.
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Commonly studied single-nucleotide polymorphisms and breast cancer: Results from the Breast Cancer Association Consortium
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Breast Cancer in African-American Women
TL;DR: African- American women face a lower risk of being diagnosed with breast cancer as compared to Caucasian-American women, yet they paradoxically face an increased breast cancer mortality hazard.
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Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Authors' reply
Martha P. Mims,Teresa G. Hayes,Shiyan Zheng,Suzanne M. Leal,Anna Frolov,Michael Ittmann,Thomas M. Wheeler,Josef T. Prchal,Jeffrey A. Canter,Asha R. Kallianpur,Fritz F. Parl,Robert C. Millikan +11 more
TL;DR: The mtDNA G10398A polymorphism alters the structure of Complex I in the mitochondrial electron transport chain, an important site of free radical production and is associated with several neurodegenerative disorders.
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