Journal ArticleDOI
Matrix Gla protein, a new γ-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone
TLDR
Matrix Gla protein this article is a 15,000 dalton protein whose amino acid composition includes a single disulfide bond and is not a precursor to bone Gla.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1983-12-28. It has received 382 citations till now. The article focuses on the topics: Matrix gla protein & Osteocalcin.read more
Citations
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Journal ArticleDOI
Vascular Calcification. Mechanisms and Clinical Ramifications
TL;DR: Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of vascular calcification, a complex, regulated process of biomineralization resembling osteogenesis, which is widely used as a clinical indicator of atherosclerosis.
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Warfarin Causes Rapid Calcification of the Elastic Lamellae in Rat Arteries and Heart Valves
TL;DR: The results indicate that the improved warfarin plus vitamin K treatment protocol developed in this study should provide a useful model to investigate the role of MGP in preventing calcification of arteries and heart valves.
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Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins
TL;DR: It is shown that restoration of MGP expression in arteries rescues the arterial mineralization phenotype of Mgp−/− mice, whereas its expression in osteoblasts prevents bone mineralization, indicating that ECMM is regulated locally in animals and uncover a striking disparity of function between proteins sharing identical structural motifs.
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Bone cell biology: the regulation of development structure, and function in the skeleton
Sandy C. Marks,Steven N. Popoff +1 more
TL;DR: Any understanding of bone cell regulation is a key ingredient in understanding not only the development, maintenance, and repair of the skeleton but also the prevention and treatment of skeletal disorders.
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New insights into the biology of osteocalcin
TL;DR: It is suggested that the ability of osteocalcin to function both locally in bone and as a hormone depends on a novel post-translational mechanism that alters osteoccin's affinity for the bone matrix and bioavailability.
References
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The preparation and enzymatic hydrolysis of reduced and S-carboxymethylated proteins.
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Effects of warfarin on bone. Studies on the vitamin K-dependent protein of rat bone.
P A Price,M K Williamson +1 more
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Presence of osteocalcin and related higher molecular weight 4-carboxyglutamic acid-containing proteins in developing bone.
TL;DR: Development of a sensitive radioimmunoassay for the vitamin K-dependent bone protein osteocalcin in avian species has provided new information on the biosynthesis of this protein in bone.
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Absence of the vitamin K-dependent bone protein in fetal rat mineral. Evidence for another gamma-carboxyglutamic acid-containing component in bone.
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Concurrent warfarin treatment further reduces bone mineral levels in 1,25-dihydroxyvitamin D3-treated rats.
P A Price,S A Sloper +1 more
TL;DR: Observations indicate that a component of the steroidal hormone action of 1,25-(OH)2D3 on bone may be mediated by increased synthesis of a vitamin K-dependent protein, which may be the bone Gla protein, the only bone specific protein whose synthesis is known to be increased by 1, 25-dihydroxyvitamin D3.