Journal ArticleDOI
Mechanisms of ammonia and ammonium ion toxicity in animal cells: transport across cell membranes.
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The results show that ammonium ion transport in the murine myeloma cell line (Sp2/0-Ag14) used is inhibited by an excess of potassium ions, and suggest that potassium ions can be used to detoxify ammonia/ammonium in animal cell cultivations.About:
This article is published in Journal of Biotechnology.The article was published on 1993-09-01. It has received 133 citations till now. The article focuses on the topics: Ammonium transport & Ammonium.read more
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NH4+ toxicity in higher plants: a critical review
TL;DR: This review discusses the major themes of NH 4 + toxicity, including the occurrence ofNH 4 + in the biosphere, response differences to NH 4+ nutrition among wild and domesticated species, symptoms and proposed mechanisms underlying toxicity, and means by which it can be alleviated.
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The importance of ammonia in mammalian cell culture
TL;DR: The main source of the ammonia which accumulates in cell cultures is glutamine, which plays an important role in the metabolism of rapidly growing cells and strategies to overcome toxic ammonia accumulation include substitution of glutamine by glutamate or other amino acids, nutrient control and removal of ammonia from the culture medium.
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The roles of free ammonia (FA) in biological wastewater treatment processes: A review.
TL;DR: FA can be leveraged to substantially enhance the biodegradability of secondary sludge, which would further improve biological nutrient removal and enhance renewable energy production.
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Ammonium toxicity in bacteria.
TL;DR: It was concluded that ammonium is not detrimental to C. glutamicum and other bacteria even when present in molar concentrations, and when growth was impaired upon addition of molar (NH4)2SO4 concentrations, this was not caused by an ammonium-specific effect but by an enhanced osmolarity or increased ionic strength of the medium.
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Monoamine oxidases as sources of oxidants in the heart.
Nina Kaludercic,Jeanne Mialet-Perez,Jeanne Mialet-Perez,Nazareno Paolocci,Angelo Parini,Angelo Parini,Fabio Di Lisa,Fabio Di Lisa +7 more
TL;DR: The role of MAO in catecholamine and serotonin clearance and cycling and cycling in relation to cardiac structure and function is discussed and both beneficial effects of their pharmacological or genetic inhibition along with potential adverse effects observed at baseline in MAO knockout mice are examined.
References
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Membrane adenosine triphosphatase as a participant in the active transport of sodium and potassium in the human erythrocyte.
TL;DR: Evidence is presented that an adenosine triphosphatase in broken human erythrocyte membranes is a part of the system for the active transport of sodium and potassium in intact ery Throthrocytes.
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Intracellular pH Transients in Squid Giant Axons Caused by CO2, NH3, and Metabolic Inhibitors
Walter F. Boron,P De Weer +1 more
TL;DR: The intracellular pH (pHi) of squid giant axons has been measured using glass pH microelectrodes and a mathematical model explains the pHi changes caused by NH4Cl on the basis of passive movements of both NH3 and NH4+.
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Mechanisms of regulation of the Na+/H+ exchanger
Sergio Grinstein,Ase Rothstein +1 more
TL;DR: An emerging pattern of information reveals striking similarities between the modes of activation of several stimuli and suggests that they may share a common mechanism in Na+/H + exchange.
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An investigation of the ionic mechanism of intracellular pH regulation in mouse soleus muscle fibres.
C. Claire Aickin,R. C. Thomas +1 more
TL;DR: Intracellular pH of surface fibres of the mouse soleus muscle was measured in vitro by recessed‐tip pH‐sensitive micro‐electrodes and the mechanism of recovery from this acidification was investigated.