Open AccessJournal Article
Mechanisms of epileptogenesis
Suzanne Clark,Wilkie A. Wilson +1 more
Reads0
Chats0
About:
This article is published in Advances in Neurology.The article was published on 1999-01-01 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Epileptogenesis.read more
Citations
More filters
Journal ArticleDOI
On the cellular and network bases of epileptic seizures
TL;DR: Although epileptic syndromes and their causes are diverse, the cellular mechanisms of seizure generation appear to fall into only two categories: rhythmic or tonic "runaway" excitation or the synchronized and rhythmic interplay between excitatory and inhibitory neurons and membrane conductances.
Journal ArticleDOI
Anticonvulsant and antiepileptic actions of 2‐deoxy‐D‐glucose in epilepsy models
Carl E. Stafstrom,Jeffrey C. Ockuly,Lauren Murphree,Matthew T. Valley,Avtar Roopra,Thomas P. Sutula +5 more
TL;DR: The effects of limiting carbohydrate availability by reducing glycolysis using the Glycolytic inhibitor 2‐deoxy‐D‐glucose (2DG) in experimental models of seizures and epilepsy are evaluated.
Journal ArticleDOI
cDNA profiling of epileptogenesis in the rat brain.
TL;DR: Assessment of hippocampal gene expression during epileptogenesis indicated that 37 genes were altered in the 1‐day group, 12 in the 4-day group and 14 in the 14‐day epilepsy group, while assessment of temporal lobe gene expression indicated 42 genes with altered expression, which are involved in neuronal plasticity, gliosis, organization of the cytoskeleton or extracellular matrix, and metabolism.
Journal ArticleDOI
Future directions for epilepsy research.
Margaret P. Jacobs,G. D. Fischbach,Michael Davis,Marc A. Dichter,Raymond Dingledine,Daniel H. Lowenstein,Martha J. Morrell,Jeffrey L. Noebels,Michael A. Rogawski,Susan S. Spencer,William H. Theodore +10 more
TL;DR: Integrated approaches, such as coupling imaging with electrophysiology, are central to progress in localizing regions of epilepsy development in people at risk and better seizure prediction and treatment for people with epilepsy.
Journal ArticleDOI
Large-scale expression study of human mesial temporal lobe epilepsy: evidence for dysregulation of the neurotransmission and complement systems in the entorhinal cortex.
Sarah Jamali,Fabrice Bartolomei,Andrée Robaglia-Schlupp,Annick Massacrier,Jean-Claude Peragut,Jean Régis,H. Dufour,Rivka Ravid,Patrice Roll,Sandrine Pereira,Barbara Royer,Nathalie Roeckel-Trevisiol,Marc Fontaine,Maxime Guye,José Boucraut,Patrick Chauvel,Pierre Cau,Pierre Szepetowski +17 more
TL;DR: The data indicate that local dysregulation of the neurotransmission and complement systems in the EC is a frequent event in human MTLE, and identifies six candidate genes for humanMTLE pathophysiology.