Journal ArticleDOI
Mechanisms of free radical oxidation of unsaturated lipids
TLDR
The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.Abstract:
The primary producs formed from the autoxidation of lipids can be understood based upon a mechanism that involves five different reaction types. These reactions are: reaction of a carbon radical and molecular oxygen, atom transfer of a hydrogen from substrate to the chain carrying peroxyl, fragmentation of the chain carrying peroxyl to give oxygen and a carbon radical, rearrangement of the peroxyl, and cyclization of the peroxyl. The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.read more
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A review on synthesis and their antibacterial activity of silver and selenium nanoparticles against biofilm forming staphylococcus aureus
TL;DR: This review focuses on the Preparation and their potential with good antimicrobial activity of Ag-Nps and Se-NPs against biofilm forming S. aureus.
Journal ArticleDOI
Effects of recombinant human erythropoietin high mimicking abuse doses on oxidative stress processes in rats
Sara Bianchi,Jonathan Fusi,Ferdinando Franzoni,Luca Giovannini,Fabio Galetta,Claudio Mannari,Emanuele Guidotti,Leonardo Tocchini,Gino Santoro +8 more
TL;DR: The results confirm the literature data regarding the antioxidant action of erythropoietin administered at low doses and for short times, whereas they showed an opposite incremental oxidative stress action when ery Anthrop ErythropOietin is administered at high doses.
Journal ArticleDOI
Mechanism and stereoselectivity of biologically important oxygenation reactions of the 7-dehydrocholesterol radical.
Ramanan Rajeev,Raghavan B. Sunoj +1 more
TL;DR: The mechanism of free radical oxygenation of 7-dehydrocholesterol (7-DHC), one of the biologically important sterols, is investigated by using density functional theory and distortion-interaction analysis of the C-O bond formation transition states suggests that the energetic preference toward the α prochiral face stems from reduced skeletal distortions of the cholesterol backbone as compared to that in the corresponding β pro chiral face.
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Lung Function and Short-Term Ambient Air Pollution Exposure: Differential Impacts of Omega-3 and Omega-6 Fatty Acids.
TL;DR: In this article , polyunsaturated omega 3 (n-3) fatty acids (FAs) appeared to attenuate the health effects of air pollution, and the associations between forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and plasma markers of inflammation (IL-6 [interleukin-6]) and oxidative stress (oxidized low-density lipoprotein]) were measured.
References
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Journal ArticleDOI
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
TL;DR: A complex process in which endothelial cells modify LDL by mechanisms involving generation of free radicals and action of phospholipase (s) is suggested, including degradation of phosphatidylcholine.
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Allylic 1,3-strain as a controlling factor in stereoselective transformations
TL;DR: In this article, the authors present a model for controlling dyadic add-ion reactions to double-branched double-bond reactions, including the following: 1.3-Strain Control of Dlastereoselective Intermolecular Addhion Reactions InvoMng Heteroallyl Systems 10.5.
Journal ArticleDOI
An introduction to free radical biochemistry
K. H. Cheeseman,T. F. Slater +1 more
TL;DR: Reactive free radicals formed within cells can oxidise biomolecules and lead to cell death and tissue injury, and establishing the involvement of free radicals in the pathogenesis of a disease is extremely difficult due to the short lifetimes of these species.
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Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro
G. W. Burton,K. U. Ingold +1 more
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Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols
Graham W. Burton,Takahisa Doba,Eric J. Gabe,L. Hughes,Florence L. Lee,L. Prasad,Keith U. Ingold +6 more
TL;DR: On mesure les constantes de vitesse de l'elimination of l'hydrogene atomique par les radicaux peroxyles de lα-tocopherol and de 35 phenols structuralement apparentes.