Journal ArticleDOI
Mechanisms of free radical oxidation of unsaturated lipids
TLDR
The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.Abstract:
The primary producs formed from the autoxidation of lipids can be understood based upon a mechanism that involves five different reaction types. These reactions are: reaction of a carbon radical and molecular oxygen, atom transfer of a hydrogen from substrate to the chain carrying peroxyl, fragmentation of the chain carrying peroxyl to give oxygen and a carbon radical, rearrangement of the peroxyl, and cyclization of the peroxyl. The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.read more
Citations
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
Journal ArticleDOI
Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants.
TL;DR: Current knowledge and advances in the understanding of oxidative processes in biological systems are summarized and this knowledge is extended to specific applications in aquatic organisms because of their sensitivity to oxidative pollutants, their filtration capacity, and their potential for environmental toxicology studies.
Journal ArticleDOI
Free Radical Lipid Peroxidation: Mechanisms and Analysis
Journal ArticleDOI
Ferroptosis: mechanisms, biology and role in disease.
TL;DR: In this paper, the authors provide a critical analysis of the current molecular mechanisms and regulatory networks of ferroptosis, the potential physiological functions of the potential therapeutic roles, and its pathological roles, together with a potential for therapeutic targeting.
Journal ArticleDOI
Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.
TL;DR: Inhibition of free radical generating enzymes is inhibition of internal antioxidant enzymes and prevention of lipid peroxidation is prevention of DNA damage and protein modification.
References
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Journal ArticleDOI
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids
TL;DR: A complex process in which endothelial cells modify LDL by mechanisms involving generation of free radicals and action of phospholipase (s) is suggested, including degradation of phosphatidylcholine.
Journal ArticleDOI
Allylic 1,3-strain as a controlling factor in stereoselective transformations
TL;DR: In this article, the authors present a model for controlling dyadic add-ion reactions to double-branched double-bond reactions, including the following: 1.3-Strain Control of Dlastereoselective Intermolecular Addhion Reactions InvoMng Heteroallyl Systems 10.5.
Journal ArticleDOI
An introduction to free radical biochemistry
K. H. Cheeseman,T. F. Slater +1 more
TL;DR: Reactive free radicals formed within cells can oxidise biomolecules and lead to cell death and tissue injury, and establishing the involvement of free radicals in the pathogenesis of a disease is extremely difficult due to the short lifetimes of these species.
Journal ArticleDOI
Autoxidation of biological molecules. 1. Antioxidant activity of vitamin E and related chain-breaking phenolic antioxidants in vitro
G. W. Burton,K. U. Ingold +1 more
Journal ArticleDOI
Autoxidation of biological molecules. 4. Maximizing the antioxidant activity of phenols
Graham W. Burton,Takahisa Doba,Eric J. Gabe,L. Hughes,Florence L. Lee,L. Prasad,Keith U. Ingold +6 more
TL;DR: On mesure les constantes de vitesse de l'elimination of l'hydrogene atomique par les radicaux peroxyles de lα-tocopherol and de 35 phenols structuralement apparentes.