Mechanistic insights and perspectives involved in neuroprotective action of quercetin
Amarjot Kaur Grewal,Thakur Gurjeet Singh,Deepak Sharma,Veerta Sharma,Manjinder Singh,Md. Habibur Rahman,Agnieszka Najda,Magdalena Walasek-Janusz,Mohamed Kamel,Ghadeer M. Albadrani,Muhammad Furqan Akhtar,Ammara Saleem,Mohamed M. Abdel-Daim +12 more
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TLDR
A review of the role of quercetin in the protection against neurodegenerative diseases (NDDs) is presented in this article, where the authors assessed the food sources and its pharmacokinetic profile, structure activity relationship and its pathophysiological role in various NDDs.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2021-08-01 and is currently open access. It has received 67 citations till now. The article focuses on the topics: Neuroprotection & PI3K/AKT/mTOR pathway.read more
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Health Benefits of Quercetin in Age-Related Diseases
Deepika,Pawan Kumar Maurya +1 more
TL;DR: A detailed review of quercetin as a curative agent in neurodegeneration, diabetes, cancer, and inflammation has been carried out and it is proved that quercETin plays a crucial role in the prevention of age-related disorders.
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Apoptotic Pathways and Alzheimer's Disease: Probing Therapeutic Potential.
Vivek Kumar Sharma,Vivek Kumar Sharma,Thakur Gurjeet Singh,Shareen Singh,Nikhil Garg,Sonia Dhiman +5 more
TL;DR: A review of diverse and versatile apoptotic mechanisms that are indispensable for neuronal survival and constitute an integral part of the pathological progression of Alzheimer's disease can be found in this paper, where the authors identify potential targets (restoring apoptotic and antiapoptotic balance, caspases, TRADD, RIPK1, FADD, TNFα, etc.) to decide the fate of neurons and to develop potential therapeutics for treatment of AD.
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Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression.
TL;DR: In this article , a review mechanistically provides an overview of the neuropathological roles of sustained neuroinflammatory response in the development of depression and elucidates the therapeutic potential of flavonoid and non-flavonoid polyphenols in modulating inflammatory mediators and signaling cascades as well as promoting other neurophysiological and neuroprotective functions underlying inflammation-associated depressive symptoms.
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Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
Zhifu Cui,Xing-Ye Zhao,Felix Kwame Amevor,Xiaxia Du,Yan Wang,Diyan Li,Gang Shu,Yaofu Tian,Xiaoling Zhao +8 more
TL;DR: Generally, SIRT1 may serve as a promising therapeutic target in the treatment of aging-related diseases via inhibiting oxidative stress, reducing inflammatory responses, and restoring mitochondrial dysfunction.
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A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders
TL;DR: This review provides an overview of available experimental data on quercetin and its complexes with respect to central nervous system diseases, with a main focus on some aspects that were not discussed previously, such as anti-anxiolytic effects, anti-Huntington’s disease activity, or therapeutic potential in brain cancer.
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Journal Article
Pharmacokinetics and bioavailability of the flavonol quercetin in humans.
TL;DR: In vivo data on the disposition, absorption, bioavailability, and metabolism of quercetin after intravenous and oral administration in humans are scarce and contradictory, and insufficient to clarify whether or not quercETin can be held responsible for any protective or curative effect observed after oral intake.
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Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons
Flaubert Tchantchou,Pascale N. Lacor,Zhiming Cao,Lixing Lao,Yan Hou,Changhai Cui,William L. Klein,Yuan Luo +7 more
TL;DR: The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB.
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Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis.
Asokan Devarajan,Noam Bourquard,Susan Hama,Mohamad Navab,Victor Grijalva,Susan Morvardi,Catherine F. Clarke,Laurent Vergnes,Karen Reue,John F. Teiber,Srinivasa T. Reddy +10 more
TL;DR: The results illustrate that the antiatherogenic effects of Pon2 are, in part, mediated by the role of PON2 in mitochondrial function.
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Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish
TL;DR: The objective of this study was to provide a scientific rationale for the clinical use of quercetin, leading to its development as an effective therapeutic agent for the treatment of Parkinson's disease.
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JNK pathway signaling: a novel and smarter therapeutic targets for various biological diseases.
Ankit Kumar,Umesh Kumar Singh,Suvarna G. Kini,Vikas Garg,Saurabh Agrawal,Praveen Kumar Tomar,Prateek Pathak,Anurag Chaudhary,Pratibha Gupta,Amrita Malik +9 more
TL;DR: The evidence supporting JNK as a potent therapeutic target, and small molecules from various chemical classes as JNK inhibitors are summarized.