Journal ArticleDOI
Nuclear Factor Erythroid 2 - Related Factor 2 Signaling in Parkinson Disease: A Promising Multi Therapeutic Target Against Oxidative Stress, Neuroinflammation and Cell Death
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TLDR
This work summarizes published reports on the potential inducers of Nrf2 that demonstrate neuroprotective effects in experimental models of PD with possible future strategies to increase the transcriptional level of NRF2 as a therapeutic strategy to provide neuroprotection of damaged dopaminergic neurons in PD.Citations
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Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases
TL;DR: Classifying bioactive compounds derived from natural products that are Nrf2/ARE pathway activators and recapitulate the molecular mechanisms for inducing NRF2 to provide favorable effects in experimental models of chronic diseases improve the treatment efficacy.
Journal Article
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.
Melinda S. Yates,Masafumi Tauchi,Fumiki Katsuoka,Kathleen C. Flanders,Karen T. Liby,Tadashi Honda,Gordon W. Gribble,Delinda A. Johnson,Jeffrey A. Johnson,Neal C. Burton,Tomás R. Guilarte,Masayuki Yamamoto,Michael B. Sporn,Thomas W. Kensler +13 more
TL;DR: Sporn et al. as discussed by the authors characterized the pharmacodynamic activity of imidazolide triterpenoid derivative, 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im or TP235), by measuring increases in Nqo1 transcript levels as a marker of cytoprotective gene induction.
Journal ArticleDOI
Nrf2 as regulator of innate immunity: A molecular Swiss army knife!
Maurizio Battino,Francesca Giampieri,Francesca Pistollato,Antoni Sureda,Marcos Roberto de Oliveira,Valeria Pittalà,Francesca Fallarino,Seyed Fazel Nabavi,Atanas G. Atanasov,Seyed Mohammad Nabavi +9 more
TL;DR: Current knowledge on Nrf2 signaling pathway structure and activity under both physiological state and upon oxidative stress is summarized, highlighting the potential therapeutic effects of diverse natural and synthetic compounds as NRF2 regulators.
Journal ArticleDOI
The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2.
Michela Campolo,Giovanna Casili,Flavia Biundo,Rosalia Crupi,Marika Cordaro,Salvatore Cuzzocrea,Salvatore Cuzzocrea,Emanuela Esposito +7 more
TL;DR: The thesis that DMF may constitute a promising therapeutic target for the treatment of PD is supported, via regulation of the NF-κB/Nrf-2 pathway, novel cytoprotective modalities that further augment the natural antioxidant response in neurodegenerative and inflammatory disease models.
Journal ArticleDOI
The Nrf2/HO-1 Axis as Targets for Flavanones: Neuroprotection by Pinocembrin, Naringenin, and Eriodictyol.
TL;DR: These compounds as exemplified by pinocembrin could induce the nuclear factor erythroid 2-related factor 2- (Nrf2-) heme oxygenase-1 (HO-1) axis leading to amelioration of oxidative stress in cellular and animal models.
References
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Journal ArticleDOI
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
TL;DR: The extent of tissue-PCD revealed by this method is considerably greater than apoptosis detected by nuclear morphology, and thus opens the way for a variety of studies.
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Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
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Mitochondrial formation of reactive oxygen species.
TL;DR: This review describes the main mitochondrial sources of reactive species and the antioxidant defences that evolved to prevent oxidative damage in all the mitochondrial compartments and discusses various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants.
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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Tetsuro Ishii,Kazuhiko Igarashi,James Douglas Engel,James Douglas Engel,Masayuki Yamamoto +7 more
TL;DR: It is postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel NRF2 nuclear shuttling mechanism.
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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
TL;DR: The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.