Journal ArticleDOI
Mice lacking MHC class II molecules
Dominic Cosgrove,David Gray,Andrée Dierich,James C. Kaufman,Marianne LeMeur,Christophe Benoist,Diane Mathis +6 more
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Some old ideas about lymphocyte differentiation have been confirmed, but some surprises are provided: a lack of germinal centers, fewer IgM+IgD+ cells in certain individuals, reduced production of serum IgG1, and complete inability to respond to T-dependent antigens.About:
This article is published in Cell.The article was published on 1991-09-06. It has received 871 citations till now. The article focuses on the topics: B-1 cell & Germinal center.read more
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MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
TL;DR: The specificity and function of mouse NK1 T cells are reviewed, the relationship of this lineage to mainstream T cells and NK cells is discussed, and the novel regulatory pathway, which straddles the innate and the adaptive immune systems, is discussed.
Journal ArticleDOI
Profound block in thymocyte development in mice lacking p56lck.
Thierry Molina,Kenji Kishihara,D. P. Siderovskid,W. van Ewijk,Arumugavadivel Narendran,Emma Timms,Andrew Wakeham,Christopher J. Paige,K.-U. Hartmann,A. Veillette,D. Davidson,T. W. Mak +11 more
TL;DR: The results illustrate the crucial role of this T-cell-specific tyrosine kinase in the thymocyte development, as Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocytes population.
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Organ-Specific Disease Provoked by Systemic Autoimmunity
Valerie Kouskoff,Anne-Sophie Korganow,Veronique Duchatelle,Claude Degott,Christophe Benoist,Diane Mathis +5 more
TL;DR: A spontaneous mouse model of RA is described, generated fortuitously by crossing a T cell receptor (TCR) transgenic line with the NOD strain, and it is suggested that human RA develops by an analogous mechanism.
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T Cell-Independent Antigens Type 2
TL;DR: Evidence demonstrating that B cell activation via TI stimuli does not play merely a permissive role in allowing for cell cycle entry and enhanced responsiveness to other stimuli is presented, rather, the nature of the B cell activating signal is critical in determining the quantitative and qualitative profile of Ig isotype production.
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Negative selection of lymphocytes.
TL;DR: This review has documented some of the influences impacting on emerging T and B cell repertoires that result in a removal of the most dangerous self-reactive cells and the progressive quantitative and qualitative increase, through positive clonal selection, of other cells specific for the actual foreign antigens encountered by each individual.
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Journal ArticleDOI
Altering the genome by homologous recombination.
TL;DR: The current status of gene targeting with particular emphasis on germ line modification of the mouse genome is discussed, and the different methods so far employed to identify those rare embryonic stem cells in which the desired targeting event has occurred are described.
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Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
Austin Smith,John K. Heath,Deborah D. Donaldson,Gordon G. Wong,Jean-François Moreau,Mark Stahl,David J. Rogers +6 more
TL;DR: DIA and human interleukin DA/leukaemia inhibitory factor have been identified as related multifunctional regulatory factors with distinct biological activities in both early embryonic and haemopoetic stem cell systems.
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Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens.
TL;DR: This paper used hybridoma monoclonal antibodies obtained after immunization of mice with rat cells to study rat cell-surface antigens present on subpopulations of rat lymphocytes.
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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4 + 8 + thymocytes
TL;DR: The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H–Y) antigen in the context of class I H–2Db MHC antigens.