Microbial Synthesis of Pinene
TLDR
It is demonstrated that the GPP concentration available to PS for cyclization alters the pinene isomer ratio, and it is speculated that pinene toxicity was limiting production; however, toxicity should not be limiting at current titers.Abstract:
The volumetric heating values of today’s biofuels are too low to power energy-intensive aircraft, rockets, and missiles. Recently, pinene dimers were shown to have a volumetric heating value simila...read more
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Fuelling the future: microbial engineering for the production of sustainable biofuels
TL;DR: This Review discusses how microorganisms can be explored for the production of next-generation biofuels, based on the ability of bacteria and fungi to use lignocellulose; through direct CO2 conversion by microalgae; using lithoautotrophs driven by solar electricity; or through the capacity of microorganisms to use methane generated from landfill.
Journal ArticleDOI
A comprehensive metabolic map for production of bio-based chemicals
Sang Yup Lee,Hyun Uk Kim,Tong Un Chae,Jae Sung Cho,Je Woong Kim,Jae Ho Shin,Dong In Kim,Ko Yoo Sung,Woo Dae Jang,Yu Sin Jang +9 more
TL;DR: This Review provides a comprehensive overview of biological and chemical routes for the synthesis of industrial chemicals derived from key precursor metabolites of central carbon metabolic pathways, and visualizes the results in a global bio-based chemicals map.
Journal ArticleDOI
Tolerance engineering in bacteria for the production of advanced biofuels and chemicals
TL;DR: Strain engineering is reviewed, primarily as it pertains to bacterial solvent tolerance, and the benefits and challenges associated with the expression of membrane-localized transporters in improving solvent tolerance and production are reviewed.
Journal ArticleDOI
Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering
TL;DR: Saccharomyces cerevisiae was engineered to produce lycopene in this study and this study provides a good reference of combinatorial engineering of host cell and heterologous pathway for microbial overproduction of pharmaceutical and chemical products.
Book ChapterDOI
Isoprenoid Drugs, Biofuels, and Chemicals—Artemisinin, Farnesene, and Beyond
Kevin W. George,Jorge Alonso-Gutierrez,Jorge Alonso-Gutierrez,Jay D. Keasling,Jay D. Keasling,Jay D. Keasling,Taek Soon Lee,Taek Soon Lee +7 more
TL;DR: A brief review of the numerous isoprenoid compounds that have found use as pharmaceuticals, flavors, commodity chemicals, and, most importantly, advanced biofuels is provided, and the metabolic engineering strategies that were used to produce these compounds successfully in microbial hosts are highlighted.
References
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Journal ArticleDOI
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