Micronutrients Deficiency, Supplementation and Novel Coronavirus Infections—A Systematic Review and Meta-Analysis
TLDR
Use of micronutrients as prophylaxis and complementary supplement in therapeutic management of COVID-19 patients may be a promising and cost-effective approach warranting in-depth investigation.Abstract:
Background: Micronutrients play roles in strengthening and maintaining immune function, but their supplementation and/or deficiency effects on respiratory tract infections are inconclusive This review aims to systematically assess the associations between micronutrient supplementation or deficiency, with novel coronavirus incidence and disease severity Methods: Systematic literature searches conducted in five electronic databases identified 751 unique studies, of which 33 studies (five supplementation studies, one supplementation and deficiency study, and 27 deficiency studies) were eventually included in this review Proportions of incidence and severity outcomes in each group, and adjusted summary statistics with their relevant 95% confidence intervaIs (CI) were extracted Data from 19 studies were pooled in meta-analysis using the generic inverse variance method Findings: A total of 360,346 patients across 16 countries, with a mean age between 32 and 877 years, were involved across 33 studies All studies were on COVID-19 infections In individuals without micronutrient deficiency, there was a significant reduction on odds of COVID-19 incidence (pooled OR: 037, 95% CI: 018, 078), and ICU admissions or severe/critical disease onset when combined as a severity outcome (pooled OR: 026, 95% CI: 008, 089) Insignificant protective effects were observed on other outcome measures, namely mortality, ICU admission, progression to respiratory-related complications, severe/critical disease onset or requiring respiratory support and hospitalization rate Conclusion: The absence of micronutrient deficiency significantly reduced COVID-19 incidence and clinical deterioration in hospitalized patients Usage of micronutrients as prophylaxis and complementary supplement in therapeutic management of COVID-19 patients may be a promising and cost-effective approach warranting in-depth investigationread more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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Vitamins, supplements and COVID-19: a review of currently available evidence.
TL;DR: In this paper, a review of clinical trials regarding vitamins and supplements for the treatment of COVID-19 infections is presented, showing significant decreases in oxygen requirements, need for ICU treatment, SARS-CoV-2 RNA test positivity, and mortality.
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Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review
Angelina Bania,Konstantinos Pitsikakis,Georgios Mavrovounis,Maria Mermiri,Eleftherios Beltsios,Antonis Adamou,Vasiliki Konstantaki,Demosthenes Makris,Vasiliki Tsolaki,Konstantinos I. Gourgoulianis,Ioannis Panagopoulos +10 more
TL;DR: Vitamin D supplements, and especially calcifediol, were shown to be useful in significantly reducing ICU admissions and/or mortality in four of the studies, but not in diminishing the duration of hospitalization of COVID-19 patients.
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Editorial: A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection
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The role of micronutrients in the management of COIVD-19 and optimizing vaccine efficacy
Noor Altooq,Ali Humood,Ahmed N Alajaimi,Ahmad F. Alenezi,Mohamed Ahmed Janahi,Omar A. Alhaj,Haitham Jahrami +6 more
TL;DR: In this article , the authors highlight the role of different micronutrients in the management of COVID-19 and optimizing vaccines, and to revile the clinical effects of micRONutrients deficiencies on patients with COVID19.
References
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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TL;DR: Although high fever was associated with the development of ARDS, it was also associated with better outcomes among patients with ARDS and treatment with methylprednisolone may be beneficial for patients who develop ARDS.
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Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data
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