Journal ArticleDOI
MicroRNA-188-5p suppresses tumor cell proliferation and metastasis by directly targeting FGF5 in hepatocellular carcinoma
TLDR
It is suggested that miR-188-5p could serve as a potential prognostic biomarker and therapeutic target for HCC, suggesting that the miRNA was significantly decreased in HCC and its expression levels were highly correlated with multiple nodules, microvascular invasion, overall and disease-free survival of HCC.About:
This article is published in Journal of Hepatology.The article was published on 2015-10-01. It has received 149 citations till now. The article focuses on the topics: Fibroblast growth factor-5 & Metastasis.read more
Citations
More filters
Journal ArticleDOI
Exosomal circRNAs: biogenesis, effect and application in human diseases
Yangxia Wang,Jinbo Liu,Junfen Ma,Ting Sun,Quanbo Zhou,Weiwei Wang,Guixian Wang,Pingjun Wu,Haijiang Wang,Li Jiang,Weitang Yuan,Zhenqiang Sun,Liang Ming +12 more
TL;DR: Although their precise roles and mechanisms of gene regulation remain largely elusive, exosomal circRNAs have potential applications as disease biomarkers and novel therapeutic targets.
Journal ArticleDOI
FGF/FGFR signaling in health and disease
Yangli Xie,Nan Su,Jing Yang,Qiaoyan Tan,Shuo Huang,Min Jin,Zhenhong Ni,Bin Zhang,Dali Zhang,Fengtao Luo,Hangang Chen,Xianding Sun,Jian Q. Feng,Huabing Qi,Lin Chen +14 more
TL;DR: A comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of F GF signaling dysregulation, is provided.
Journal ArticleDOI
MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST
TL;DR: It is shown that miR-92b was significantly upregulated in tumor tissue and plasma of HCC patients, and its expression level was highly correlated with gender and microvascular invasion, and the importance of XIST/miR- 92b/Smad7 signaling axis in HCC progression is revealed for the first time.
Journal ArticleDOI
Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation.
Xiangyu Dai,Chao Chen,Qianlei Yang,Junchao Xue,Xiong Chen,Baofei Sun,Fei Luo,Xinlu Liu,Tian Xiao,Hui Xu,Qian Sun,Aihua Zhang,Qizhan Liu +12 more
TL;DR: The results showed that circRNA_100284 is involved in the malignant transformation of L-02 cells induced by arsenite, and the concept that exosomal circRNAs are involved in cell–cell communication during carcinogenesis induced by arsenalite is supported.
Journal ArticleDOI
Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition.
Shuai Xiao,Rui-Min Chang,Ming-Yang Yang,Xiong Lei,Xiao Liu,Wen-Bin Gao,Jing-Lei Xiao,Lian-Yue Yang +7 more
TL;DR: It is found that ACTL6A plays an essential role in metastasis and EMT of HCC and is indicated as a prognostic biomarker candidate and a potential therapeutic target for HCC.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
Journal ArticleDOI
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
TL;DR: In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of the gene set.
Journal ArticleDOI
miRBase: annotating high confidence microRNAs using deep sequencing data.
Ana Kozomara,Sam Griffiths-Jones +1 more
TL;DR: An update of the miRBase database is described, including the collation and use of deep sequencing data sets to assign levels of confidence to miR base entries, and a high confidence subset of miR Base entries are provided, based on the pattern of mapped reads.
Journal ArticleDOI
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
TL;DR: It is demonstrated that a temporal gradient in Lin-14 protein is generated posttranscriptionally by multiple elements in the lin-14 3'UTR that are regulated by the heterochronic gene Lin-4.