Journal ArticleDOI
MicroRNA 23b regulates autophagy associated with radioresistance of pancreatic cancer cells.
Peng Wang,Juan Zhang,Juan Zhang,Li Zhang,Zhengfei Zhu,Jie Fan,Lianyu Chen,Liping Zhuang,Jianmin Luo,Hao Chen,Luming Liu,Zheng Chen,Zhiqiang Meng +12 more
TLDR
Reduced levels of the miRNA miR-23b increase levels of ATG12 and autophagy to promote radioresistance and might be used to increase the sensitivity of pancreatic cancer cells to radiation therapy.About:
This article is published in Gastroenterology.The article was published on 2013-11-01. It has received 207 citations till now. The article focuses on the topics: Pancreatic cancer & Radioresistance.read more
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MicroRNAs in apoptosis, autophagy and necroptosis.
TL;DR: This work summarizes how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression and discusses how mi RNAs link different types of cell death.
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Modulation of inflammation by autophagy: Consequences for human disease
TL;DR: The crosstalk between autophagy and inflammation is focused on as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand.
Journal ArticleDOI
PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways
Lei Chang,Peter Graham,Jingli Hao,Jie Ni,Joseph Bucci,Paul J. Cozzi,John H. Kearsley,Yong Li +7 more
TL;DR: The findings from this study suggest that the combination of dual PI3K/Akt/mTOR inhibitors (BEZ235 or PI103) with radiotherapy is a promising modality for the treatment of CaP to overcome radioresistance.
Journal ArticleDOI
Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer.
Hu YiRen,Yu YingCong,Yu YingCong,You Sunwu,Li Keqin,Tong Xiaochun,Chen Senrui,Chen Ende,Lin XiZhou,Lin XiZhou,Chen Yanfan +10 more
TL;DR: A novel mechanism of lncRNA-regulated autophagy-related chemoresistance in GC is revealed, casting new lights on the understanding ofChemoresistance.
Journal ArticleDOI
Mitochondrion-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation.
Chris Y. Y. Yu,Huae Xu,Shenglu Ji,Ryan T. K. Kwok,Jacky Wing Yip Lam,Xiaolin Li,Xiaolin Li,Sunil Krishnan,Dan Ding,Ben Zhong Tang +9 more
TL;DR: increasing intracellular level of 1O2 originated from mitochondria is demonstrated to be a generic method to enhance the radiosensitivity of cancer cells with a supra‐additive synergistic effect of “0 + 1 > 1.”
References
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Cancer statistics, 2012
TL;DR: The reduction in overall cancer death rates since 1990 in men and 1991 in women translates to the avoidance of about 1,024,400 deaths from cancer, which can be accelerated by applying existing cancer control knowledge across all segments of the population, with an emphasis on those groups in the lowest socioeconomic bracket.
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Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
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Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lee P. Lim,Nelson C. Lau,Philip W. Garrett-engele,Andrew Grimson,Janell M. Schelter,John C. Castle,David P. Bartel,Peter S. Linsley,Jason M. Johnson +8 more
TL;DR: These results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts, and seem to downregulate a far greater number of targets than previously appreciated.