Journal ArticleDOI
Microtubule polymerization dynamics
Reads0
Chats0
TLDR
This review describes progress toward understanding the mechanism of dynamic instability of pure tubulin and discusses the function and regulation of microtubule dynamic instability in living cells.Abstract:
The polymerization dynamics of microtubules are central to their biological functions. Polymerization dynamics allow microtubules to adopt spatial arrangements that can change rapidly in response to cellular needs and, in some cases, to perform mechanical work. Microtubules utilize the energy of GTP hydrolysis to fuel a unique polymerization mechanism termed dynamic instability. In this review, we first describe progress toward understanding the mechanism of dynamic instability of pure tubulin and then discuss the function and regulation of microtubule dynamic instability in living cells.read more
Citations
More filters
Journal ArticleDOI
Signaling Mechanisms Regulating Endothelial Permeability
Dolly Mehta,Asrar B. Malik +1 more
TL;DR: This review summarizes and analyzes the recent data from genetic, physiological, cellular, and morphological studies that have addressed the signaling mechanisms involved in the regulation of both the paracellular and transcellular transport pathways.
Journal ArticleDOI
Doublecortin is a microtubule-associated protein and is expressed widely by migrating neurons.
TL;DR: It is demonstrated that DCX is expressed in migrating neurons throughout the central and peripheral nervous system during embryonic and postnatal development and likely directs neuronal migration by regulating the organization and stability of microtubules.
Journal ArticleDOI
Microtubule assembly, organization and dynamics in axons and dendrites.
Cecilia Conde,Alfredo Cáceres +1 more
TL;DR: Current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites is reviewed to provide new insight into microtubules' function in neuronal development and their potential contribution to plasticity.
Journal ArticleDOI
Tracking the ends: a dynamic protein network controls the fate of microtubule tips
TL;DR: This work has shown that microtubule plus-end tracking proteins, a diverse group of evolutionarily conserved cellular factors that accumulate at the ends of growing microtubules, form dynamic networks through the interaction of a limited set of protein modules, repeat sequences and linear motifs that bind to each other with moderate affinities.
Journal ArticleDOI
Regulation of Actin Filament Assembly by Arp2/3 Complex and Formins
TL;DR: This review summarizes what is known about the biochemical and biophysical mechanisms that initiate the assembly of actin filaments in cells and focuses on Arp2/3 complex and formins.
References
More filters
Book
Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
Journal ArticleDOI
Cell Migration: A Physically Integrated Molecular Process
TL;DR: The authors are grateful for financial support from the National Institutes of Health (grants GM23244 and GM53905), and to very helpful comments on the manuscript from Elliot Elson, Vlodya Gelfand, Paul Matsudaira, Julie Theriot, and Sally Zigmond.
Journal ArticleDOI
Dynamic instability of microtubule growth
TL;DR: It is reported here that microtubules in vitro coexist in growing and shrinking populations which interconvert rather infrequently and this dynamic instability is a general property of micro Tubules and may be fundamental in explaining cellular microtubule organization.
PatentDOI
COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII)
TL;DR: In this article, the complete 1.66-megabase pair genome sequence of an autotrophic archaeon, Methanococcus jannaschii, and its 58 and 16-kilobase pair extrachromosomal elements are described.
Journal ArticleDOI
Crystal structure of the Aequorea victoria green fluorescent protein.
TL;DR: The green fluorescent protein (GFP) from the Pacific Northwest jellyfish Aequorea victoria has generated intense interest as a marker for gene expression and localization of gene products.