Journal ArticleDOI
Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?
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TLDR
The fact that telomere length correlates with the final inhibition of proliferation under conditions of varied oxidative stress, while the population doubling level does not, suggests that telitere shortening provides the signal for cell cycle exit in senescence.About:
This article is published in Experimental Cell Research.The article was published on 1995-09-01. It has received 863 citations till now. The article focuses on the topics: Telomere & Stress-induced premature senescence.read more
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Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
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Oxidants, oxidative stress and the biology of ageing.
Toren Finkel,Nikki J. Holbrook +1 more
TL;DR: Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
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Accelerated telomere shortening in response to life stress
Elissa S. Epel,Elizabeth H. Blackburn,Jue Lin,Firdaus S. Dhabhar,Nancy E. Adler,Jason D. Morrow,Richard M. Cawthon +6 more
TL;DR: Evidence is provided that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, in peripheral blood mononuclear cells from healthy premenopausal women.
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Oxidative stress shortens telomeres
TL;DR: It is suggested here that oxidative stress is an important modulator of telomeres loss and that telomere-driven replicative senescence is primarily a stress response.
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Mitochondria, oxygen free radicals, disease and ageing
Sandeep Raha,Brian H. Robinson +1 more
TL;DR: In this article, the transformation of superoxide into hydrogen peroxide and, under certain conditions, then into hydroxyl radicals is important in diseases where respiratory chain function is abnormal or where superoxide dismutase function is altered.