Journal ArticleDOI
Oxidative stress shortens telomeres
TLDR
It is suggested here that oxidative stress is an important modulator of telomeres loss and that telomere-driven replicative senescence is primarily a stress response.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2002-07-01. It has received 2125 citations till now. The article focuses on the topics: Telomere & Telomerase.read more
Citations
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Journal ArticleDOI
Accelerated telomere shortening in response to life stress
Elissa S. Epel,Elizabeth H. Blackburn,Jue Lin,Firdaus S. Dhabhar,Nancy E. Adler,Jason D. Morrow,Richard M. Cawthon +6 more
TL;DR: Evidence is provided that psychological stress--both perceived stress and chronicity of stress--is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length, in peripheral blood mononuclear cells from healthy premenopausal women.
Journal ArticleDOI
Aging, Cellular Senescence, and Cancer
TL;DR: The idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are at least partly linked by a common biological phenomenon: a cellular stress response known as cellular senescence is discussed.
Journal ArticleDOI
The role of senescent cells in ageing
TL;DR: A deeper understanding of the molecular mechanisms underlying the multi-step progression of senescence and the development and function of acute versus chronic senescent cells may lead to new therapeutic strategies for age-related pathologies and extend healthy lifespan.
Journal ArticleDOI
Understanding the odd science of aging
TL;DR: To understand the cell and molecular basis of aging is to unravel the multiplicity of mechanisms causing damage to accumulate and the complex array of systems working to keep damage at bay.
Journal ArticleDOI
Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.
Florence Debacq-Chainiaux,Jorge D. Erusalimsky,Judith Campisi,Judith Campisi,Olivier Toussaint +4 more
TL;DR: A cytochemical protocol suitable for the histochemical detection of individual senescent cells both in culture and tissue biopsies is described and the fluorescence-based methods have the advantages of being more quantitative and sensitive.
References
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Journal ArticleDOI
The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
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Telomeres shorten during ageing of human fibroblasts.
TL;DR: The amount and length of telomeric DNA in human fibroblasts does in fact decrease as a function of serial passage during ageing in vitro and possibly in vivo.
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Extension of life-span by introduction of telomerase into normal human cells
Andrea G. Bodnar,Michel M. Ouellette,Maria Frolkis,Shawn E. Holt,Choy-Pik Chiu,Gregg B. Morin,Calvin B. Harley,Jerry W. Shay,Serge Lichtsteiner,Woodring E. Wright +9 more
TL;DR: In this article, two telomerase-negative normal human cell types, retinal pigment epithelial cells and foreskin fibroblasts, were transfected with vectors encoding the human telomere catalytic subunit.
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Identification of a specific telomere terminal transferase activity in tetrahymena extracts
TL;DR: It is proposed that the novel telomere terminal transferase is involved in the addition of telomeric repeats necessary for the replication of chromosome ends in eukaryotes.
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A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
TL;DR: Marginotomy is responsible for the loss with age of various cell clones of the body, including some endocrine cell clones, and may be the primary cause of various disorders of age of the ageing of multicellular organisms.