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Mitral valve endocarditis caused by Pseudomonas aeruginosa: a case report

TLDR
A case of a high-risk patient with coronary artery disease and left-ventricular dysfunction, successfully treated for pseudomonal mitral valve endocarditis complicated by splenic abscess formation, is presented here.
Abstract
Previously, endocarditis caused by Pseudomonas aeruginosa mostly involved right-sided valvular infection and generally carried a good prognosis. Recently, changes have been observed in the occurrence and clinical presentation of pseudomonal endocarditis, with increasing incidence of nosocomial infections and involvement of the aortic and mitral valves. Still, pseudomonal left-sided endocarditis is rare, but is frequently associated with complications and high mortality rates. A case of a high-risk patient with coronary artery disease and left-ventricular dysfunction, successfully treated for pseudomonal mitral valve endocarditis complicated by splenic abscess formation, is presented here.

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Cellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa.

TL;DR: It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect, and this review highlights the possible manifestations of PCN exposure.
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In vitro activity of ceftolozane/tazobactam against clinical isolates of Pseudomonas aeruginosa in the planktonic and biofilm states.

TL;DR: The combination of the novel cephalosporin, ceftolozane, with the β-lactamase inhibitor, tazobactam, is tested against planktonic and biofilm forms of 54 clinical isolates of P. aeruginosa, using cefepime as a comparator.
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Non-nosocomial healthcare-associated left-sided Pseudomonas aeruginosa endocarditis: a case report and literature review.

TL;DR: This case illustrates the importance of identifying the causative pathogen(s), especially for outpatients with a recent history of medical procedures, and a combination therapy with anti-pseudomonal beta-lactams or carbapenems and aminoglycosides may be the preferable treatment.
Journal ArticleDOI

Pyocyanin is the Microbial blue-green Pigment: A review on its History, Virulence, and Therapeutic Use

TL;DR: In this article , a bibliographic search of scientific literature published up to 2020 was conducted using scientific databases and search engines, and the data were retrieved independently from eligible papers using the usual data extraction approach.
References
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Journal ArticleDOI

Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa.

TL;DR: It is suggested that bloodstream infections due to P aeruginosa have a greater risk of hospital mortality compared to bloodstream infectionsDue to S aureus despite adequate antibiotic treatment.
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The Etiology and Persistence of Cryptic Bacterial Infections: A Hypothesis

TL;DR: Antibiotics used to treat sequestered infections should be tested against populations of pathogens in intact biofilms to determine the ability of the antibiotics to penetrate the glycocalyces and to kill the component bacteria.
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Current best practices and guidelines: Indications for surgical intervention in infective endocarditis

TL;DR: In this paper, the authors proposed a sound clinical judgment based on extensive experience for optimal diagnosis and management of patients with infective endocarditis, which is especially important in regard to the indications and timing for surgery.
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Management of splenic abscess: report on 16 cases from a single center

TL;DR: US-guided percutaneous aspiration of splenic abscesses is a safe and effective procedure that can be used as a bridge to surgery in patients who are critically ill or have several comorbidities.
Journal ArticleDOI

Current best practices and guidelines. Assessment and management of complications in infective endocarditis.

TL;DR: This review focuses on the cardiac, embolic, neurologic and renal complications of endocarditis and discusses how these complications influence the clinical management of individual cases in daily practice.