Journal ArticleDOI
Models of Acute and Chronic Pancreatitis
Markus M. Lerch,Fred S. Gorelick +1 more
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TLDR
Animal models of acute and chronic pancreatitis have been created to examine mechanisms of pathogenesis, test therapeutic interventions, and study the influence of inflammation on the development of pancreatic cancer.About:
This article is published in Gastroenterology.The article was published on 2013-05-01. It has received 313 citations till now. The article focuses on the topics: Pancreatitis & Autoimmune pancreatitis.read more
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Journal ArticleDOI
Cholecystokinin Receptor Antagonist Therapy Decreases Inflammation and Fibrosis in Chronic Pancreatitis
Sandeep Nadella,Victor Ciofoaia,Victor Ciofoaia,Hong Cao,Bhaskar Kallakury,Robin D Tucker,Jill P. Smith +6 more
TL;DR: Proglumide therapy decreased pancreatic weight in the CDE diet study and the cerulein-induced chronic pancreatitis model and the decrease in ADM may reduce the risk of the development of pancreatic cancer.
Journal ArticleDOI
Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice
Qixiang Mei,Guoying Deng,Zehua Huang,Yue Yin,Chunlin Li,Jun-Hui Hu,Yang Fu,Xingpeng Wang,Yue Zeng +8 more
TL;DR: Porous COS@SiO2 nanocomposites activate the Nrf2 signaling pathway to inhibit oxidative stress and reduce the expression of NF-κB and the NLRP3 inflammasome and the release of inflammatory factors, thus blocking the systemic inflammatory response and ultimately ameliorating SAP and associated lung injury.
Journal ArticleDOI
The rise of genetically engineered mouse models of pancreatitis: A review of literature.
Troy L. Merry,Maxim S. Petrov +1 more
TL;DR: An overview of the genetically engineered mouse models that spontaneously develop pancreatitis is given and those that most closely replicate different pancreatitis hallmarks observed in humans are discussed.
Journal ArticleDOI
Spautin-A41 Attenuates Cerulein-Induced Acute Pancreatitis through Inhibition of Dysregulated Autophagy.
Kai Dong,Chen Xia,Liping Xie,Lanting Yu,Mengjun Shen,Yanping Wang,Shanshan Wu,Jiajia Wang,Junxi Lu,Gang Wei,Dongliang Xu,Dongliang Xu,Liu Yang +12 more
TL;DR: Mechanistically, spautin-A41 effectively reduced the expression levels of Class III phosphatidylinositol 3 (PI3) kinase complexes and subsequently ameliorated pancreatitis by inhibiting the formation of autophagosome and may serve as new target for treating or lessening the severity of AP.
Journal ArticleDOI
P53 Activated by ER Stress Aggravates Caerulein-Induced Acute Pancreatitis Progression by Inducing Acinar Cell Apoptosis
Lei Zhou,Jie-hui Tan,Wan-Yan Zhou,Jia Xu,Shi-jing Ren,Zhen-yu Lin,Xue-mei Chen,Guo-wei Zhang +7 more
TL;DR: P53, which was activated by the ER stress pathway, promoted the progression of AP in mice expressing PRSS1 by inducing acinar cell apoptosis.
References
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Journal ArticleDOI
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene.
David C. Whitcomb,Michael C. Gorry,Preston Ra,William Furey,Michael Sossenheimer,Charles D. Ulrich,Stephen P. Martin,Lawrence K. Gates,Stephen T. Amann,Phillip P. Toskes,Roger A. Liddle,Kevin McGrath,Generoso Uomo,James Christopher Post,James Christopher Post,Garth D. Ehrlich +15 more
TL;DR: X-ray crystal structure analysis, molecular modelling, and protein digest data indicate that the Arg 117 residue is a trypsin-sensitive site, and that loss of this cleavage site would permit autodigestion resulting in pancreatitis.
Acute pancreatitis
TL;DR: There is a wide spectrum of disease from mild (80%), where patients recover within a few days, to severe (20%) with prolonged hospital stay, the need for critical care support, and a 15-20% risk of death.
Journal ArticleDOI
International consensus diagnostic criteria for autoimmune pancreatitis: guidelines of the International Association of Pancreatology.
Tooru Shimosegawa,Suresh T. Chari,Luca Frulloni,Terumi Kamisawa,Shigeyuki Kawa,Mari Mino-Kenudson,Myung-Hwan Kim,Günter Klöppel,Markus M. Lerch,Matthias Löhr,Kenji Notohara,Kazuichi Okazaki,Alexander Schneider,Lizhi Zhang +13 more
TL;DR: The categorization of AIP into types 1 and 2 should be helpful for further clarification of the clinical features, pathogenesis, and natural history of these diseases.
Journal ArticleDOI
Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival
Heather P. Harding,Huiqing Zeng,Yuhong Zhang,Rivka Jungries,Peter Chung,Heidi Plesken,David D. Sabatini,David Ron +7 more
TL;DR: Findings suggest a special role for translational control in protecting secretory cells from ER stress in diabetes mellitus and exocrine pancreatic insufficiency.
Journal ArticleDOI
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Carmen Guerra,Alberto J. Schuhmacher,Marta Cañamero,Paul J. Grippo,Lena Verdaguer,Lucía Pérez-Gallego,Pierre Dubus,Eric P. Sandgren,Mariano Barbacid +8 more
TL;DR: It is reported that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acINs or their precursors into ductal-like cells.