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Acute Pancreatitis: Bench to the Bedside
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This article is published in Gastroenterology.The article was published on 2007-03-01. It has received 617 citations till now. The article focuses on the topics: Acute pancreatitis.read more
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Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
TL;DR: The concept of neutrophils phenotypic and functional heterogeneity is presented and several neutrophil subpopulations reported to date are described and the role these sub Populations seem to play in homeostasis and disease is discussed.
Journal ArticleDOI
Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis.
Maxim S. Petrov,Satyanarayan T. Shanbhag,Mandira Chakraborty,Anthony R. J. Phillips,John A. Windsor +4 more
TL;DR: In patients with acute pancreatitis, the absolute influence of OF and IPN on mortality is comparable and thus the presence of either indicates severe disease and the relative risk of mortality doubles when of both are both present.
Journal ArticleDOI
Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis.
Bechien U. Wu,James Q. Hwang,Timothy H. Gardner,Kathryn Repas,Ryan Delee,Song Yu,Benjamin N. Smith,Peter A. Banks,Darwin L. Conwell +8 more
TL;DR: Patients with acute pancreatitis who were resuscitated with lactated Ringer's solution had reduced systemic inflammation compared with those who received saline.
Journal ArticleDOI
Interventions for necrotizing pancreatitis: summary of a multidisciplinary consensus conference.
Martin L. Freeman,Jens Werner,Hjalmar C. van Santvoort,Todd H. Baron,Marc G. Besselink,John A. Windsor,Karen D. Horvath,Eric vanSonnenberg,Thomas L. Bollen,Santhi Swaroop Vege +9 more
TL;DR: Intervention is primarily indicated for infected necrosis, less often for symptomatic sterile necrotizing pancreatitis, and should ideally be delayed as long as possible, preferably 4 weeks or longer after the onset of disease, for better demarcation and liquefaction of the necrosis.
Journal ArticleDOI
Acute pancreatitis: Etiology and common pathogenesis
TL;DR: It is hypothesize that acute biliary pancreatitis and other causes of acute pancreatitis possess a common pathogenesis and traditional therapeutic strategies against acute Pancreasitis may be improved.
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.
Journal ArticleDOI
IAP family proteins—suppressors of apoptosis
Quinn Deveraux,John C. Reed +1 more
TL;DR: Although the mechanism used by the IAPs to suppress cell death remains debated, several studies have provided insights into the biochemical functions of these intriguing proteins and a variety of reports have suggested an important role for the I APs in some human diseases.
Journal ArticleDOI
NF-κB at the crossroads of life and death
Michael Karin,Anning Lin +1 more
TL;DR: The choice between life and death is one of the major events in regulation of the immune system and a major regulator of such life or death decisions is the transcription factor NF-κB as mentioned in this paper.
Journal ArticleDOI
A Clinically Based Classification System for Acute Pancreatitis: Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 Through 13, 1992
TL;DR: In the absence of accepted definitions for acute pancreatitis and its complications, it has not been possible to devise a clinical classification system useful for case management as discussed by the authors, which is why a group of 40 international authorities from six medical disciplines and 15 countries participated in a three-day meeting and open discussion.
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