Journal ArticleDOI
Models of Acute and Chronic Pancreatitis
Markus M. Lerch,Fred S. Gorelick +1 more
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TLDR
Animal models of acute and chronic pancreatitis have been created to examine mechanisms of pathogenesis, test therapeutic interventions, and study the influence of inflammation on the development of pancreatic cancer.About:
This article is published in Gastroenterology.The article was published on 2013-05-01. It has received 313 citations till now. The article focuses on the topics: Pancreatitis & Autoimmune pancreatitis.read more
Citations
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Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.
Jing Xue,Vishal Sharma,Michael H. Hsieh,Ajay Chawla,Ramachandran Murali,Stephen J. Pandol,Aida Habtezion +6 more
TL;DR: It is shown that pharmacologic inhibition of IL-4/IL-13 in human ex-vivo studies as well as in established mouse CP decreases pancreatic AAMs and fibrosis, and identifies a critical role for macrophages in pancreatic fibrosis and in turn PSCs as important inducers of macrophage alternative activation.
Journal ArticleDOI
Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models
György Biczó,Eszter T. Vegh,Natalia Shalbueva,Olga A. Mareninova,Jason M. Elperin,Ethan Lotshaw,Sophie Gretler,Aurelia Lugea,Sudarshan R. Malla,David W. Dawson,Piotr Ruchala,Julian P. Whitelegge,Samuel W. French,Li Wen,Sohail Z. Husain,Fred S. Gorelick,Péter Hegyi,Péter Hegyi,Zoltán Rakonczay,Ilya Gukovsky,Anna S. Gukovskaya +20 more
TL;DR: In different animal models, a central role is found for mitochondrial dysfunction, and for impaired autophagy as its principal downstream effector, in development of AP, a model of severe AP the pathogenesis of which has remained unknown.
Journal ArticleDOI
Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models.
Li Wen,Svetlana Voronina,Muhammad A. Javed,Muhammad Awais,Peter Szatmary,Peter Szatmary,Diane Latawiec,Michael Chvanov,D. Collier,Wei Huang,John Barrett,Malcolm Begg,Kenneth A. Stauderman,Jack Roos,Sergey Grigoryev,Stephanie Ramos,Evan Rogers,Jeff Whitten,Gonul Velicelebi,Michael Dunn,Alexei V. Tepikin,David N. Criddle,Robert Sutton +22 more
TL;DR: Cytosolic calcium overload, mediated via ORAI1, contributes to the pathogenesis of acute pancreatitis.
Journal ArticleDOI
Regeneration and repair of the exocrine pancreas.
TL;DR: The NFκB signaling pathway is a critical determinant of pancreatic inflammation and metaplasia, whereas a number of developmental signals and transcription factors are devoted to promoting acinar redifferentiation after injury.
Journal ArticleDOI
Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes
Kalliope N. Diakopoulos,Marina Lesina,S Wörmann,Liang Song,Michaela Aichler,Lorenz Schild,Anna Artati,Werner Römisch-Margl,Thomas Wartmann,Robert Fischer,Yashar Kabiri,Hans Zischka,Walter Halangk,Ihsan Ekin Demir,Claudia Pilsak,Axel Walch,Christos S. Mantzoros,Jörg M. Steiner,Mert Erkan,Roland M. Schmid,Heiko Witt,Jerzy Adamski,Hana Algül +22 more
TL;DR: Dietary antioxidants, especially in combination with palm oil-derived fatty acids, blocked progression to CP and pancreatic acinar atrophy and might be used to identify therapeutic targets for CP.
References
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Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis
Heiko Witt,W Luck,Hans Christian Hennies,M Classen,A. Kage,U Lass,Olfert Landt,Michael Becker +7 more
TL;DR: Analysis of the gene encoding the serine protease inhibitor, Kazal type 1, a pancreatic trypsin inhibitor, indicates that mutations in SPINK1 are associated with chronic pancreatitis.
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Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue.
Michaela Lampel,Horst F. Kern +1 more
TL;DR: Conscious rats infused via a jugular vein catheter with 5×10−6 g/kg/h caerulein for periods up to 24 h showed a progressive reduction in the in vitro sensitivity of the pancreatic cells to secretory proteins, which corresponds largely to a reduction of cellular respiration.
Journal ArticleDOI
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis
Walter Halangk,Markus M. Lerch,B. Brandt-Nedelev,Wera Roth,Manuel Ruthenbuerger,Thomas Reinheckel,Wolfram Domschke,Hans Lippert,Christoph Peters,Jan M. Deussing +9 more
TL;DR: These experiments provide the first conclusive evidence to the authors' knowledge that cathepsin B plays a role in intrapancreatic trypsinogen activation and the onset of acute pancreatitis.
Journal ArticleDOI
Action of secretagogues on a new preparation of functionally intact, isolated pancreatic acini.
TL;DR: It is concluded that the decreased response (desensitization) is a postreceptor phenomenon and possibly mediated by Ca2+ itself.