Journal ArticleDOI
Modification of human low-density lipoprotein by the lipid peroxidation product 4-hydroxynonenal.
Reads0
Chats0
TLDR
Compared to malonaldehyde, 4-hydroxynonenal exhibits a much higher capacity to modify LDL and it is believed that this aldehyde is a more likely candidate for being responsible for LDL modification under in vivo lipid peroxidation conditions.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1986-01-03. It has received 235 citations till now. The article focuses on the topics: Lipoprotein & Apolipoprotein B.read more
Citations
More filters
Journal ArticleDOI
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
TL;DR: This review provides a comprehensive summary on the chemical properties of 4-hydroxyalkenals and malonaldehyde, the mechanisms of their formation and their occurrence in biological systems and methods for their determination, as well as the many types of biological activities described so far.
Journal ArticleDOI
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.
TL;DR: A comprehensive survey on the compositional properties of LDL relevant for its susceptibility to oxidation, on the mechanism and kinetics of LDL oxidation, and on the chemical and physico-chemical properties of HDL oxidized by exposure to copper ions is provided.
Journal ArticleDOI
Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.
Seppo Ylä-Herttuala,Wulf Palinski,Michael E. Rosenfeld,Sampath Parthasarathy,Thomas E. Carew,Susan Butler,Joseph L. Witztum,Daniel Steinberg +7 more
TL;DR: Three lines of evidence are presented that low density lipoproteins gently extracted from human and rabbit atherosclerotic lesions (lesion LDL) greatly resembles LDL that has been oxidatively modified in vitro.
Journal ArticleDOI
Biochemistry of Oxidative Stress
TL;DR: Diverse biological processes such as inflammation, carcinogenesis, ageing, radiation damage and photobiological effects appear to involve reactive oxygen species, and oxidative stress denotes a shift in the prooxidant/antioxidant balance in favor of the former.
Journal ArticleDOI
Autoxidation of human low density lipoprotein: loss of polyunsaturated fatty acids and vitamin E and generation of aldehydes.
TL;DR: The rate and extent of the change of LDL constituents occurring during lipid peroxidation is reported for the first time, and 4-hydroxynonenal was most effective, followed by 2,4-heptadienal, hexanal, and malonaldehyde.
References
More filters
Journal ArticleDOI
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis
Klaus Weber,Mary Osborn +1 more
TL;DR: The results show that the polyacrylamide gel electrophoresis method can be used with great confidence to determine the molecular weights of polypeptide chains for a wide variety of proteins.
Journal ArticleDOI
The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Joseph L. Goldstein,M. S. Brown +1 more
TL;DR: The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.
Journal ArticleDOI
Lipoprotein metabolism in the macrophage: Implications for cholesterol deposition in atherosclerosis
TL;DR: The cholesteryl Ester/Protein Complexes from Atherosclerotic Plaques and the Foam Cell in Familial Hypercholesterolemia are studied.
Journal ArticleDOI
Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.
TL;DR: The results suggest that cells modifying LDL do so in part by an oxidation of LDL subsequent to cellular generation of free radicals.
Journal ArticleDOI
Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids☆
TL;DR: Investigations suggest that as compared to 4-hydroxynonenal very low amounts of other 4-Hydroxyalkenals are formed by actively peroxidizing liver microsomes, and this finding may help to elucidate the mechanism by which lipid peroxidation causes deleterious effects on cells and cell constituents.