Journal ArticleDOI
Modifying intracellular redox balance: an approach to improving therapeutic index
William J. M. Hrushesky,William J. M. Hrushesky,Patricia A. Wood,Patricia A. Wood,Randal Olshefski,Randal Olshefski,Steven R. Meshnick,Steven R. Meshnick,John Wallace Eaton,John Wallace Eaton +9 more
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TLDR
Clinical trials of the effect of methylene-blue on the toxic therapeutic ratio of doxorubicin and other oxidative quinone drugs should be considered.About:
This article is published in The Lancet.The article was published on 1985-03-09. It has received 30 citations till now. The article focuses on the topics: Therapeutic index & Doxorubicin.read more
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Primary and secondary mechanisms of action of visible to near-IR radiation on cells.
TL;DR: A cascade of reactions connected with alteration in cellular homeostasis parameters (pHi, [Cai], cAMP, Eh, [ATP] and some others) is considered as a photosignal transduction and amplification chain in a cell (secondary mechanisms).
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Free radical formation by antitumor quinones
TL;DR: The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated and it is suggested that cardiotoxicity and skin toxicity may also be related to oxygen radical formation.
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Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways
Hani Atamna,Andy Nguyen,Carla S. Schultz,Kathleen Boyle,Justin Newberry,Hiroyuki Kato,Bruce N. Ames +6 more
TL;DR: It is proposed that the cellular senescence delay caused by MB is due to cycling between MB and MBH2 in mitochondria, which may partly explain the increase in specific mito‐chondrial activities.
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Alternative Mitochondrial Electron Transfer as a Novel Strategy for Neuroprotection
Yi Wen,Wenjun Li,Ethan Poteet,Luokun Xie,Cong Tan,Liang-Jun Yan,Xiaohua Ju,Ran Liu,Hai Qian,Marian Marvin,Matthew S. Goldberg,Hua She,Zixu Mao,James W. Simpkins,Shao-Hua Yang +14 more
TL;DR: Methylene blue functions as an alternative electron carrier, which accepts electrons from NADH and transfers them to cytochrome c and bypasses complex I/III blockage, and indicates that rerouting mitochondrial electron transfer by MB or similar molecules provides a novel strategy for neuroprotection against both chronic and acute neurological diseases involving mitochondrial dysfunction.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Adriamycin: the role of lipid peroxidation in cardiac toxicity and tumor response
Charles E. Myers,William McGuire,Robert H. Liss,Ina Ifrim,Karen R. Grotzinger,Robert C. Young +5 more
TL;DR: The results suggest that adriamycin has at least two mechanisms of tissue damage: one, which involves lipid peroxidation, is blocked by tocopherol and results in cardiac toxicity; the other, which consists of binding to DNA, is not antagonized by toCophero and is responsible for tumor response.
Journal Article
A general mechanism for microsomal activation of quinone anticancer agents to free radicals.
TL;DR: It is proposed that the intracellular activation of these quinone anticancer drugs to a free radical state may be primary to their cytotoxic activity.
Journal Article
Effect of Anthracycline Antibiotics on Oxygen Radical Formation in Rat Heart
TL;DR: In this paper, the effect of the anthracycline antitumor agents on reactive oxygen metabolism in rat heart was examined, and it was shown that free radical formation by the antimalarial agents may damage the heart by exceeding the oxygen radical detoxifying capacity of cardiac mitochondria and sarcoplasmic reticulum.
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Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycin.
Joel Goodman,Paul Hochstein +1 more
TL;DR: The experiments suggest that the formation of oxygen radicals followed by lipid peroxidation may be the basis for the cardiotoxic effects of these drugs.