Journal ArticleDOI
Molecular and practical aspects of the enzymatic properties of human serum albumin and of albumin–ligand complexes
TLDR
Human serum albumin is useful in detoxification reactions, for activating prodrugs, and for binding and activating drug conjugates, and can be used to construct smart nanotubes with enzymatic properties useful for biomedical applications.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2013-12-01. It has received 98 citations till now. The article focuses on the topics: Human serum albumin & Serum albumin.read more
Citations
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Journal ArticleDOI
Human serum albumin, systemic inflammation, and cirrhosis
TL;DR: Human serum albumin (HSA) is one of the most frequent treatments in patients with decompensated cirrhosis, and its ability to bind lipopolysaccharide and other bacterial products, reactive oxygen species, nitric oxide and other nitrogen reactive species, and prostaglandins is an outstanding feature.
Journal ArticleDOI
Interactive Association of Drugs Binding to Human Serum Albumin
Feng Yang,Yao Zhang,Hong Liang +2 more
TL;DR: This review will succinctly outline the properties of binding site of drugs in IIA subdomain within the structure of HSA to give an overview on the binding characterization of interactive association of drugs to human serum albumin that may potentially lead to significant clinical applications.
Journal ArticleDOI
Biophysical Study on the Interaction between Eperisone Hydrochloride and Human Serum Albumin Using Spectroscopic, Calorimetric, and Molecular Docking Analyses.
TL;DR: Thermodynamic analysis shows HSA-EH complex formation occurs primarily due to hydrophobic interactions, and hydrogen bonds were facilitated at the binding of EH, helping to understand the activity and mechanism of drug binding.
Journal ArticleDOI
Binding of Tolperisone Hydrochloride with Human Serum Albumin: Effects on the Conformation, Thermodynamics, and Activity of HSA
TL;DR: This extensive study provides additional insight of ligand binding and structural changes induced in HSA relevant to the biological activity of HSA in vivo.
Journal ArticleDOI
Role of albumin in diseases associated with severe systemic inflammation: Pathophysiologic and clinical evidence in sepsis and in decompensated cirrhosis
TL;DR: There are many data indicating that the therapeutic action of albumin is mediated not only through the impact on plasma volume expansion but also through a modulatory effect on inflammation and oxidative stress, relevant to diseases associated with systemic inflammation including sepsis and decompensated cirrhosis.
References
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Book ChapterDOI
Structure of serum albumin.
Daniel C. Carter,Joseph X. Ho +1 more
TL;DR: This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin and suggests that AFP may have a higher affinity for some unknown ligands important for fetal development.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
Journal ArticleDOI
Structural Basis of the Drug-Binding Specificity of Human Serum Albumin.
TL;DR: Crystallographic analysis of 17 different complexes of HSA with a wide variety of drugs and small-molecule toxins reveals the precise architecture of the two primary drug-binding sites on the protein, identifying residues that are key determinants of binding specificity and illuminating the capacity of both pockets for flexible accommodation.
Journal ArticleDOI
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites
TL;DR: The crystal structure of HSA complexed with five molecules of myristate at 2.5 Å resolution is determined and it is shown that fatty acid molecules bind in long, hydrophobic pockets capped by polar side chains, many of which are basic.