Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates
TLDR
Methods of integrating aptamers specific for a wide range of targets are first introduced and compared to antibodies, and applications of these systems as fluorescent, colorimetric, magnetic resonance imaging, and electrochemical sensors in medical diagnostics are given, along with new applications as smart drug delivery agents.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2010-04-30 and is currently open access. It has received 274 citations till now. The article focuses on the topics: Aptamer & Targeted drug delivery.read more
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Chemistry, Biology, and Medicine of Fluorescent Nanomaterials and Related Systems: New Insights into Biosensing, Bioimaging, Genomics, Diagnostics, and Therapy
Jun Yao,Mei Yang,Yixiang Duan +2 more
TL;DR: This research presents new insights into Biosensing, Bioimaging, Genomics, diagnostics, Diagnostics, and Therapy from the research center of Analytical Instrumentation at Sichuan University.
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Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy.
TL;DR: Future prospects for targeting CSCs for cancer therapies by using a variety of nanomaterials are highlighted and it remains an open question how nanommaterials can meet future demands for targeting and eradicating of C SCs.
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Cancer active targeting by nanoparticles: a comprehensive review of literature
TL;DR: A comprehensive review of literatures focusing on the active targeting of nanoparticles to cancer cells, including antibody and antibody fragment-based targeting, antigen-basedtargeting, aptamer- based targeting, as well as ligand-based aiming, are presented.
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Ligand-directed active tumor-targeting polymeric nanoparticles for cancer chemotherapy.
TL;DR: With promise to maximize therapeutic efficacy while minimizing systemic side effects, ligand-mediated active tumor-targeting treatment modality has become an emerging and indispensable platform for safe and efficient cancer therapy.
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A DNAzyme-gold nanoparticle probe for uranyl ion in living cells.
TL;DR: It is demonstrated that this DNAzyme-AuNP probe can readily enter cells and can serve as a metal ion sensor within a cellular environment, making it the first demonstration of DNAzymes as intracellular metal ion sensors.
References
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TL;DR: In this article, surface-enhanced Raman scattering was used to detect single molecules and single nanoparticles at room temperature with the use of surface enhanced Raman, and the intrinsic Raman enhancement factors were on the order of 10 14 to 10 15, much larger than the ensemble-averaged values derived from conventional measurements.
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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
Craig Tuerk,Larry Gold +1 more
TL;DR: High-affinity nucleic acid ligands for a protein were isolated by a procedure that depends on alternate cycles of ligand selection from pools of variant sequences and amplification of the bound species.
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