Molecular Genetics of Human Hypertension: Role of Angiotensinogen
Pierre Corvol,Xavier Jeunemaitre +1 more
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TLDR
This work has shown that AGT variants and complications of diabetes, obesity, and blood pressure, as well as the role of AGT in disease and other diseases, are driven by the same underlying mechanisms, namely hormonal regulation and gene targeting.Abstract:
I. Introduction II. Structure of the AGT Gene III. Characteristics of AGT A. AGT as the substrate for renin B. AGT as a member of the serpin superfamily: other roles for AGT? IV. Tissue and Cellular Distribution V. Regulation A. Hormonal regulation of AGT B. Regulation of AGT in disease C. Regulation of AGT gene transcription VI. Molecular Genetics of AGT in Human Essential Hypertension A. Strategies B. Linkage studies C. Association studies of AGT polymorphism and high blood pressure D. Pregnancy-induced hypertension E. M235T variants, plasma AGT concentration, and blood pressure F. Association of AGT variants with the renal blood flow response to Ang II infusion VII. Molecular Genetics of AGT and Other Diseases A. AGT variants and coronary heart disease B. AGT variants and complications of diabetes C. AGT, obesity, and blood pressure VIII. Effects of AGT Gene Variants and Gene Targeting on Ang I Production and Blood Pressure A. Human studies B. Genetic studies in rats and mice C. Genetic hypertension in...read more
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Essential Hypertension Part I: Definition and Etiology
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Vascular Inflammation and the Renin-Angiotensin System
TL;DR: A molecular mechanism for a biological positive-feedback loop that explains how vascular inflammation can be self-sustaining through upregulation of the vessel wall Ang II tone is defined, suggesting that one mechanism by which RAS antagonists prevent atherosclerosis is by reducing vascular inflammation.
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Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor.
TL;DR: The role of the type-2 receptor in the vascular and renal responses to physiological increases in angiotensin II (ANG II) in mice with targeted deletion of the AT2 receptor gene was investigated in this paper.
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Renin-angiotensin system, natriuretic peptides, obesity, metabolic syndrome, and hypertension: an integrated view in humans.
TL;DR: An integrated view of the dysregulation of these two antagonistic systems in human obesity complicated with hypertension, metabolic syndrome, and increased cardiovascular risk is proposed.
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Involvement of Tumor Necrosis Factor-α in Angiotensin II–Mediated Effects on Salt Appetite, Hypertension, and Cardiac Hypertrophy
TL;DR: It is suggested that TNF-α plays a mechanistic role in mediating chronic Ang II–induced effects on salt appetite and blood pressure, as well as on cardiac hypertrophy.
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