Journal ArticleDOI
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
TLDR
The goal of this review is to provide a comprehensive description of T-type currents, their distribution, regulation, pharmacology, and cloning.Abstract:
T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because they can be activated by small depolarizations of the plasma membrane. In many neurons Ca2+ influx through L...read more
Citations
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Journal ArticleDOI
International Union of Pharmacology. XLVIII. Nomenclature and Structure-Function Relationships of Voltage-Gated Calcium Channels
TL;DR: The molecular relationships and physiological functions of these calcium channel proteins are presented and comprehensive information on their molecular, genetic, physiological, and pharmacological properties is provided.
Journal ArticleDOI
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
TL;DR: The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrate, vertebrates, and finally to mammals, but over the centuries it had only been known for its toxicity and environmental hazard.
Journal ArticleDOI
Computational Methods in Drug Discovery
TL;DR: Computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over three decades and theory behind the most important methods and recent successful applications are discussed.
Journal ArticleDOI
The neurobiology of antiepileptic drugs.
TL;DR: The subtle biophysical modifications in channel behaviour that are induced by AEDs are often functionally opposite to defects in channel properties that are caused by mutations associated with epilepsy in humans.
Journal ArticleDOI
Molecular Physiology of Cardiac Repolarization
TL;DR: It has become clear that cardiac ion channels function as components of macromolecular complexes, comprising the alpha-subunits, one or more accessory subunit, and a variety of other regulatory proteins, suggesting important functional links between channel complexes, as well as between cardiac structure and electrical functioning.
References
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Book
Ionic channels of excitable membranes
TL;DR: The Ionic Channel of Excitable Membranes (ICOMB) as discussed by the authors is an extended version of ICOMB with new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology.
Journal ArticleDOI
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity
Declan A. Doyle,João H.Morais Cabral,Richard A. Pfuetzner,Anling Kuo,Jacqueline M. Gulbis,Steven L. Cohen,Brian T. Chait,Roderick MacKinnon +7 more
TL;DR: The architecture of the pore establishes the physical principles underlying selective K+ conduction, which promotes ion conduction by exploiting electrostatic repulsive forces to overcome attractive forces between K+ ions and the selectivity filter.
Journal ArticleDOI
Thalamocortical oscillations in the sleeping and aroused brain
TL;DR: Analysis of cortical and thalamic networks at many levels, from molecules to single neurons to large neuronal assemblies, with a variety of techniques, is beginning to yield insights into the mechanisms of the generation, modulation, and function of brain oscillations.
Journal ArticleDOI
Three types of neuronal calcium channel with different calcium agonist sensitivity.
TL;DR: Evidence is reported for the coexistence of three types of Ca channel in sensory neurones of the chick dorsal root ganglion and the dihydropyridine Ca agonist Bay K 8644 strongly increases the opening probability of L-, but not T- or N-type channels.