Journal ArticleDOI
Molecular Physiology of Cardiac Repolarization
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TLDR
It has become clear that cardiac ion channels function as components of macromolecular complexes, comprising the alpha-subunits, one or more accessory subunit, and a variety of other regulatory proteins, suggesting important functional links between channel complexes, as well as between cardiac structure and electrical functioning.Abstract:
The heart is a rhythmic electromechanical pump, the functioning of which depends on action potential generation and propagation, followed by relaxation and a period of refractoriness until the next...read more
Citations
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Journal ArticleDOI
Hyperpolarization-activated cation channels: from genes to function.
TL;DR: Recent insights into the structure, function, and cellular regulation of HCN channels are summarized and evidence on the role of individual HCN channel types arising from the analysis ofHCN knockout mouse models is discussed.
Journal ArticleDOI
Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation
TL;DR: The changes in ion channel and transporter properties associated with three important clinical and experimental paradigms: congestive heart failure, myocardial infarction, and atrial fibrillation are reviewed and important opportunities for improved therapeutic approaches are highlighted.
Journal ArticleDOI
hERG K+ Channels: Structure, Function, and Clinical Significance
TL;DR: The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which is the gene product involved in chromosome 7-associated long QT syndrome (LQTS), an inherited disorder associated with a markedly increased risk of ventricular arrhythmias and sudden cardiac death.
Journal ArticleDOI
Genesis and Regulation of the Heart Automaticity
Matteo E. Mangoni,Joël Nargeot +1 more
TL;DR: Evidence on the functional role of different families of ion channels in cardiac pacemaking is discussed and recent results obtained on genetically engineered mouse strains displaying dysfunction in heart automaticity are reviewed.
Journal ArticleDOI
Role of the Autonomic Nervous System in Atrial Fibrillation: Pathophysiology and Therapy
TL;DR: In this article, the authors focus on the relationship between the autonomic nervous system and the pathophysiology of atrial fibrillation and the potential benefit and limitations of neuromodulation in the management of this arrhythmia.
References
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Journal ArticleDOI
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
Book
Cardiac Electrophysiology : From Cell to Bedside
Douglas P. Zipes,José Jalife +1 more
TL;DR: Part I - Molecular Bases Of Ion Channel Activity PART II - Biophysics and Regulation of Cardiac Ion Channels PART III - Pharmacology of Card cardiac Ion Ch channels PART IV - Cellular Electrophysiology PART V - Models of Cardiopulmonary Excitation PART VI - Neural Control ofCardiac Electrical Activity
Journal ArticleDOI
A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
TL;DR: The finding that HERG encodes IKr channels provides a mechanistic link between certain forms of inherited and acquired LQT, and that an additional subunit may be required for drug sensitivity.