Journal ArticleDOI
Molecular Transformations in Sarcolasmic Reticulum of Fast‐Twitch Muscle by Electro‐Stimulation
Claus Heilmann,Dirk Pette +1 more
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The parallel time course of changes in contractile properties of stimulated muscle and the molecular and functional properties of the sarcoplasmic reticulum emphasizes the definitive role of the latter in determining the twitch characteristics of fast and slow twitch muscles.Abstract:
Chronic electro-stimulation of fast-twitch rabbit muscle with the frequency pattern received by a slow-twitch muscle induces a progressive transformation of the sarcoplasmic reticulum. After 2 days stimulation activities of Ca2+-dependent ATPase and of Ca2+ transport begin to decrease, and are paralleled by a progressive decrease in Ca2+-dependent and Ca2+, Mg2+-dependent phosphoprotein formation, reduced rate of dephosphorylation and a rearrangement of the electrophoretic polypeptide and phosphoprotein patterns. These findings suggest a transformation of the sarcoplasmic reticulum to resemble that of a slow-twitch muscle. This transformation is paralleled by increase in time-to-peak of twitch contraction and half relaxation time and occurs before conversion of the myosin light chain pattern is observed. The parallel time course of changes in contractile properties of stimulated muscle and the molecular and functional properties of the sarcoplasmic reticulum emphasizes the definitive role of the latter in determining the twitch characteristics of fast and slow twitch muscles.read more
Citations
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Skeletal muscle adaptability : Significance for metabolism and performance
TL;DR: The sections in this article are: Fiber Composition in Human Skeletal Muscle, Motor Unit Recruitment, Adaptive Response, and Significance of Adaptation.
OtherDOI
Skeletal Muscle Adaptability: Significance for Metabolism and Performance
Bengt Saltin,Philip D. Gollnick +1 more
TL;DR: The sections in this article are:============\/\/\/\/\/\/£££1.11\/\/£2.10\/\/£3\/\/£4\/\/£5\/\/£6.1\/\/£7.2\/\/£8\/\/£9\/\/£10\/\/ £1.7\/\/£11.5\/\/ £2.9\/\/ £3£3£4£4 £6.2£5.3£7\/\/ £7.4£8£9.5£10.2 £7======
Book ChapterDOI
Cellular and molecular diversities of mammalian skeletal muscle fibers
Dirk Pette,Robert S. Staron +1 more
Journal ArticleDOI
The adaptive response of skeletal muscle to increased use
Stanley Salmons,Jan Henriksson +1 more
TL;DR: The adaptive potential of muscle provedes a logical framework for understanding neural influences on the emergence of fiber types during muscle development and is also relevant to the study of pathological conditions which may involve a sustained departure from normal postural and locomotor patterns of activity.
Journal ArticleDOI
Neural control of phenotypic expression in mammalian muscle fibers.
Dirk Pette,Gerta Vrbová +1 more
TL;DR: In this paper, the authors summarized the present knowledge about the mechanisms involved in the control of the phenotypic expression of mammalian muscle fibers and discussed how the activity imposed on the muscle fibers by the motoneuron finally induces in the muscle cells the expression of those genes that define its particular phenotype.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis
Klaus Weber,Mary Osborn +1 more
TL;DR: The results show that the polyacrylamide gel electrophoresis method can be used with great confidence to determine the molecular weights of polypeptide chains for a wide variety of proteins.
Journal ArticleDOI
Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinases.
TL;DR: A modified procedure for purification of the adenosine 3',5'-monophosphate-dependent (cyclic AMP-dependent) protein kinase from rabbit skeletal muscle is described, which results in the separation of the enzyme into two peaks of activity on diethylaminoethylcellulose.
Journal ArticleDOI
The influence of activity on some contractile characteristics of mammalian fast and slow muscles
Stanley Salmons,Gerta Vrbová +1 more
TL;DR: The time course of contraction and relaxation in the isometric twitch of a rabbit soleus muscle becomes more rapid following tenotomy and spinal cord section, and this increase in speed could be prevented by long‐term electrical stimulation at frequencies of 5 or 10/sec.
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The influence of activity on some contractile characteristics of mammalian fast and slow muscles
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