Journal ArticleDOI
Molybdenum-containing hydroxylases.
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TLDR
The present minireview summarizes recent mechanistic and structure/function studies of members of the molybdenum-containing hydroxylases, a large and growing family of enzymes.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2005-01-01. It has received 299 citations till now.read more
Citations
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Molybdenum cofactors, enzymes and pathways
TL;DR: The biosynthetic pathways leading to both types of cofactor have common mechanistic aspects relating to scaffold formation, metal activation and cofactor insertion into apoenzymes, and have served as an evolutionary 'toolbox' to mediate additional cellular functions in eukaryotic metabolism.
Journal ArticleDOI
Distribution, diversity and ecology of aerobic CO-oxidizing bacteria
Gary M. King,Carolyn F. Weber +1 more
TL;DR: This work presents a newly emerging picture of the distribution, diversity and ecology of aerobic CO-oxidizing bacteria in soils and the oceans.
Journal ArticleDOI
Cell biology of molybdenum
Ralf R. Mendel,Florian Bittner +1 more
TL;DR: The transition element molybdenum (Mo) is of essential importance for (nearly) all biological systems as it is required by enzymes catalyzing diverse key reactions in the global carbon, sulfur and nitrogen metabolism.
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Aldehyde oxidase: an enzyme of emerging importance in drug discovery.
TL;DR: Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340.
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To be or not to be an oxidase: challenging the oxygen reactivity of flavoenzymes.
TL;DR: A survey of known 3D structures of flavin-dependent oxidases and dehydrogenases and the correlation with their functional properties indicates that there are no structural rules that enable prediction of whether or how a flavoenzyme reacts with oxygen.
References
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Journal ArticleDOI
Natural engineering principles of electron tunnelling in biological oxidation-reduction.
TL;DR: The 14 Å or less spacing of redox centres provides highly robust engineering for electron transfer, and may reflect selection against designs that have proved more vulnerable to mutations during the course of evolution.
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The Mononuclear Molybdenum Enzymes
TL;DR: It is now well-established that all molybdenum-containing enzymes other than nitrogenase fall into three large and mutually exclusive families, as exemplified by the enzymes xanthine oxidation, sulfite oxidase, and DMSO reductase; these enzymes represent the focus of the present account.
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Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: Structure-based mechanism of conversion
TL;DR: The crystal structure of the dimeric bovine milk XDH is presented and the major changes that occur on the proteolytic transformation of XDH to the XO form are described, reflecting the switch of substrate specificity observed for the two forms of this enzyme.
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Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase
TL;DR: The crystal structure of the tungsten-containing aldehyde ferredoxin oxidoreductase (AOR) from Pyrococcus furiosus, a hyperthermophilic archaeon that grows optimally at 100 degrees C, has been determined at 2.3 angstrom resolution by means of multiple isomorphous replacement and multiple crystal form averaging.