Journal ArticleDOI
Monitoring of environmental cancer initiators through hemoglobin adducts by a modified Edman degradation method
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TLDR
Derivatizing the protein in formamide solution with pentafluorophenyl isothiocyanate, using a 2H-alkylated protein as internal standard, and applying on-column injection during analysis permit reproducible determination of hydroxyethylvaline and other adducts down into the dose range where cancer risks may be considered acceptably low.About:
This article is published in Analytical Biochemistry.The article was published on 1986-04-01. It has received 308 citations till now. The article focuses on the topics: Edman degradation & Isothiocyanate.read more
Citations
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Human biomonitoring: state of the art.
TL;DR: HBM can identify new chemical exposures, trends and changes in exposure, establish distribution of exposure among the general population, identify vulnerable groups and populations with higher exposures and identify environmental risks at specific contaminated sites with relatively low expenditure, making it an ideal instrument for risk assessment and risk management.
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EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain), 2015. Scientific Opinion on acrylamide in food
TL;DR: The European Food Safety Authority (EFSA) evaluated 43 419 analytical results from food commodities and concluded that the current levels of dietary exposure to acrylamide are not of concern with respect to non-neoplastic effects as mentioned in this paper.
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Human exposure and internal dose assessments of acrylamide in food
E. Dybing,Peter B. Farmer,Melvin E. Andersen,Timothy R. Fennell,Sam P.D. Lalljie,D.J.G. Müller,Stephen S. Olin,Barbara J. Petersen,Josef Rudolf Schlatter,Gabriele Scholz,Joseph Scimeca,N. Slimani,Margareta Törnqvist,S. Tuijtelaars,Philippe Verger +14 more
TL;DR: The data on acrylamide levels in food including its formation and analytical methods, the determination of human consumption patterns, dietary intake of the general population, estimation of maximum intake levels and identification of groups of potentially high intakes are reviewed.
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Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications.
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Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment
James A. Swenberg,Kun Lu,Benjamin C. Moeller,Lina Gao,Patricia B. Upton,Jun Nakamura,Thomas B. Starr +6 more
TL;DR: 30 years of research on three "known human carcinogens": formaldehyde, vinyl chloride (VC), and ethylene oxide (EO) are utilizes, which outlines quantitative data on endogenous adducts, mutagenicity, and relationships between endogenous and exogenousAdducts.
References
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Journal ArticleDOI
A Protein Sequenator
TL;DR: The protein sequenator is an instrument for the automatic determination of amino acid sequences in proteins and peptides that operates on the principle of the phenylisothiocyanate degradation scheme and has been applied to the whole molecule of apomyoglobin from the humpback whale.
Journal Article
Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules
E C Miller,J A Miller +1 more
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On the Mechanism of the Phenyl Isothiocyanate Degradation of Peptides.
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Genetic toxicity of some important epoxides
L. Ehrenberg,S. Hussain +1 more
TL;DR: Determination of the rad-equivalence of genetic risks, i.e. the use of corresponding risks from a unit dose of ionizing radiation as a standard, indicates that the risks associated with Threshold Limit Values for epoxides in work environments in Western countries are 1–2 orders of magnitude higher than permissible risks for radiological workers.