Moody microbiome: Challenges and chances.
Po-Hsiu Kuo,Yu-Chu Ella Chung +1 more
TLDR
Results from recent clinical trials support for the beneficial effects of probiotics on alleviating depressive symptoms and increasing well-beings and modifying the composition of gut microbiota via antibiotics can be a viable adjuvant treatment option for individuals with depressive symptoms.About:
This article is published in Journal of the Formosan Medical Association.The article was published on 2019-03-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Microbiome & Gut–brain axis.read more
Citations
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Stress and the gut microbiota-brain axis
Guadalupe Molina-Torres,Miguel Rodriguez-Arrastia,Pablo Roman,Nuria Sánchez-Labraca,Diana Cardona +4 more
TL;DR: The influence of stress on gut microbiota and gut microbiota on stress modulation is clear for different stressors, but although the preclinical evidence is so extensive, the clinical evidence is more limited.
Journal ArticleDOI
Exploration of microbiota targets for major depressive disorder and mood related traits.
Yu-Chu Ella Chung,Hsi-Chung Chen,Hsiang-Chin Lori Chou,I-Ming Chen,Meei-Shyuan Lee,Li-Chung Chuang,Yen-Wenn Liu,Mong Liang Lu,Chun-Hsin Chen,Chi-Shin Wu,Ming-Chyi Huang,Shih-Cheng Liao,Yen-Hsuan Ni,Mei-Shu Lai,Wei-Liang Shih,Po-Hsiu Kuo +15 more
TL;DR: Pathway analyses revealed that pentose phosphate and starch and sucrose metabolism processes were important pathways for depression via microbiota functions, and microbiota targets for depression that are independent of fat intake were revealed.
Journal ArticleDOI
Probiotics and prebiotics: focus on psychiatric disorders - a systematic review.
TL;DR: Although recent findings in specific psychiatric disorders are encouraging, the use of prebiotics and probiotics in clinical practice stills lacks sufficiently robust evidence.
Journal ArticleDOI
Gut microbiome patterns depending on children's psychosocial stress: Reports versus biomarkers.
Nathalie Michels,Tom Van de Wiele,Fiona Fouhy,Siobhain M. O'Mahony,Gerard Clarke,James Keane +5 more
TL;DR: Even in this young healthy population, stress parameters were cross-sectionally associated with gut microbial composition but this relationship was instrument specific.
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The role of the gut-brain axis in depression: endocrine, neural, and immune pathways.
Anastasios P Makris,Minois Karianaki,Konstantinos I. Tsamis,Konstantinos I. Tsamis,Stavroula A Paschou,Stavroula A Paschou +5 more
TL;DR: The bidirectional link between the gut and the brain is of great importance for the development of novel therapeutic strategies against depression, offering promising alternatives to limited efficacy antidepressants, while combination therapy also remains a potential treatment option.
References
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Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
John F. Cryan,Timothy G. Dinan +1 more
TL;DR: The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
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Animal models of neuropsychiatric disorders
Eric J. Nestler,Steven E. Hyman +1 more
TL;DR: The current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder, is reviewed and it is argued for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders.
Journal ArticleDOI
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Undine E. Lang,Stefan Borgwardt +1 more
TL;DR: The neurodegenerative hypothesis of depression explains decreased hippocampal volumes in depressed patients and changes of neurotrophic support by BDNF, erythropoietin, GDNF, FGF-2, NT3, NGF and growth hormone.
Journal ArticleDOI
Altered fecal microbiota composition in patients with major depressive disorder
Hai-yin Jiang,Zongxin Ling,Yong-Hua Zhang,Hongjin Mao,Zhanping Ma,Yan Yin,Weihong Wang,W.H. Wilson Tang,Zhonglin Tan,Jianfei Shi,Lanjuan Li,Bing Ruan +11 more
TL;DR: Fecal samples from 46 patients with depression are analyzed to enable a better understanding of changes in the fecal microbiota composition in such patients, showing either a predominance of some potentially harmful bacterial groups or a reduction in beneficial bacterial genera.
Journal ArticleDOI
Estimating the true global burden of mental illness.
TL;DR: It is argued that the global burden of mental illness is underestimated and the reasons for under-estimation are examined to identify five main causes: overlap between psychiatric and neurological disorders; the grouping of suicide and self-harm as a separate category; conflation of all chronic pain syndromes with musculoskeletal disorders; exclusion of personality disorders from disease burden calculations; and inadequate consideration of the contribution of severe mental illness to mortality from associated causes.
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Melancholic microbes: a link between gut microbiota and depression?
Timothy G. Dinan,John F. Cryan +1 more