Journal ArticleDOI
Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system.
Y. Motato,María José de los Santos,María José Escribá,Belén Aparicio Ruiz,José Remohí,Marcos Meseguer +5 more
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TLDR
Two multivariable models are proposed based on the findings to classify embryos according to their probabilities of blastocyst stage and implantation in the largest data set ever reported of human blastocysts.About:
This article is published in Fertility and Sterility.The article was published on 2016-02-01. It has received 146 citations till now. The article focuses on the topics: Blastocyst & Embryo transfer.read more
Citations
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Deep learning as a predictive tool for fetal heart pregnancy following time-lapse incubation and blastocyst transfer
TL;DR: A retrospective analysis demonstrating that the deep learning model has a high level of predictability of the likelihood that an embryo will implant and may improve the effectiveness of previous approaches used for time-lapse imaging in embryo selection.
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Development of a generally applicable morphokinetic algorithm capable of predicting the implantation potential of embryos transferred on Day 3
TL;DR: The algorithm presented here can be used independently of culture conditions and fertilization method and provides predictive power not surpassed by other published algorithms for ranking embryos according to their blastocyst formation potential.
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Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and 'OMICS': is looking good still important?
David K. Gardner,Basak Balaban +1 more
TL;DR: It is proposed that key features, such as multinucleation, cell size and blastocyst differentiation should be included in future iterations of selection/deselection algorithms.
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Proof of concept: preimplantation genetic screening without embryo biopsy through analysis of cell-free DNA in spent embryo culture media
TL;DR: Two novel findings are demonstrated: the presence of free embryonic DNA in spent media and a result that is consistent with trophectoderm biopsy that may allow for PGS without biopsy in the future.
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Delayed blastulation, multinucleation, and expansion grade are independently associated with live-birth rates in frozen blastocyst transfer cycles
Nina Desai,Stephanie Ploskonka,Linnea R. Goodman,Marjan Attaran,Jeffrey M. Goldberg,C. Austin,Tommaso Falcone +6 more
TL;DR: The blastocyst expansion grade after warming was predictive of successful outcomes independent of the inner cell mass or trophectoderm score and delayed blastulation and multinucleation were independently associated with lower live-birth rates in frozen cycles.
References
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Journal ArticleDOI
The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting
Basak Balaban,Daniel R. Brison,Gloria Calderón,James Catt,Joe Conaghan,Lisa Cowan,Thomas Ebner,David K. Gardner,Thorir Hardarson,Kersti Lundin,M. Cristina Magli,David Mortimer,Sharon T. Mortimer,Santiago Munné,Dominique Royere,L.A. Scott,Johan Smitz,Alan R. Thornhill,Jonathan Van Blerkom,Etienne Van den Abbeel +19 more
TL;DR: It is expected that the definition of common terminology and standardization of laboratory practice related to embryo morphology assessment will result in more effective comparisons of treatment outcomes.
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The use of morphokinetics as a predictor of embryo implantation
TL;DR: A multivariable model is proposed based on the findings to classify embryos according to their probability of implantation and it is proposed that the image acquisition and time-lapse analysis system makes it possible to determine exact timing of embryo cleavages in a clinical setting.
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Non-invasive imaging of human embryos before embryonic genome activation predicts development to the blastocyst stage
Wong Connie C,Kevin E. Loewke,Nancy L. Bossert,Barry Behr,Christopher J. De Jonge,Thomas M. Baer,Renee A. Reijo Pera +6 more
TL;DR: It is found that success in progression to the blastocyst stage can be predicted with >93% sensitivity and specificity by measuring three dynamic, noninvasive imaging parameters by day 2 after fertilization, before embryonic genome activation (EGA).
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Culture and transfer of human blastocysts increases implantation rates and reduces the need for multiple embryo transfers
David K. Gardner,Pauline Vella,Michelle Lane,L Wagley,Terry Schlenker,William B. Schoolcraft +5 more
TL;DR: Viable human blastocysts can be obtained in sequential culture media in the absence of coculture and serum and will facilitate high PRs while limiting the number of embryos transferred and therefore minimizes the risk of multiple gestation.
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International Committee for Monitoring Assisted Reproductive Technologies (ICMART) world report: assisted reproductive technology 2004
Elizabeth A. Sullivan,Fernando Zegers-Hochschild,Ragaa T. Mansour,Osamu Ishihara,J. de Mouzon,Karl G. Nygren,G.D. Adamson +6 more
TL;DR: There was an increase in the use of ICSI, single embryo transfer (SET) and frozen embryos transfer (FET) and there was a decline in the multiple delivery rate (DR) and preterm birth rate in 2006.