Muscle and bone plasticity after spinal cord injury: review of adaptations to disuse and to electrical muscle stimulation
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TLDR
The paralyzed musculoskeletal system retains a remarkable degree of plasticity after spinal cord injury, and physiological levels of electrically induced muscular loading hold promise for preventing post-SCI BMD decline.Abstract:
The paralyzed musculoskeletal system retains a remarkable degree of plasticity after spinal cord injury (SCI). In response to reduced activity, muscle atrophies and shifts toward a fast-fatigable phenotype arising from numerous changes in histochemistry and metabolic enzymes. The loss of routine gravitational and muscular loads removes a critical stimulus for maintenance of bone mineral density (BMD), precipitating neurogenic osteoporosis in paralyzed limbs. The primary adaptations of bone to reduced use are demineralization of epiphyses and thinning of the diaphyseal cortical wall. Electrical stimulation of paralyzed muscle markedly reduces deleterious post-SCI adaptations. Recent studies demonstrate that physiological levels of electrically induced muscular loading hold promise for preventing post-SCI BMD decline. Rehabilitation specialists will be challenged to develop strategies to prevent or reverse musculoskeletal deterioration in anticipation of a future cure for SCI. Quantifying the precise dose of stress needed to efficiently induce a therapeutic effect on bone will be paramount to the advancement of rehabilitation strategies.read more
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References
More filters
Journal ArticleDOI
Bone “mass” and the “mechanostat”: A proposal
TL;DR: The observed fit of bone mass to a healthy animal's typical mechanical usage indicates some mechanism or mechanisms monitor that usage and control the three longitudinal growth, bone modeling, and BMU‐based remodeling activities that directly determine bone mass.
Report of the Task Group on Reference Man
TL;DR: As this report of the task group on reference man, it will really give you the good idea to be successful.
Journal ArticleDOI
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle
Christopher E. Henderson,Heidi S. Phillips,Richard A. Pollock,Alun M. Davies,Corinne Lemeulle,Mark Armanini,Lora C. Simpson,Barbara Moffet,Richard Vandlen,Vassilis E. Koliatsos,Arnon Rosenthal +10 more
TL;DR: Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture and to be a good candidate for treatment of motoneuron disease.
Journal ArticleDOI
Bone's mechanostat: A 2003 update
TL;DR: The mechanostat hypothesis predicts 32 things that occur, including the gross anatomical bone abnormalities in osteogenesis imperfecta; it distinguishes postnatal situations from baseline conditions at birth, and it provides functional definitions of mechanical bone competence, bone quality, osteopenias, and osteoporoses.