Muscle Stem Cells: A Model System for Adult Stem Cell Biology.
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TLDR
Background in the field is provided and recent advances in the understanding of muscle stem cell function and dysfunction are discussed, particularly in the case of aging, and the potential involvement of Muscle stem cells in genetic diseases such as the muscular dystrophies are discussed.Abstract:
Skeletal muscle stem cells, originally termed satellite cells for their position adjacent to differentiated muscle fibers, are absolutely required for the process of skeletal muscle repair and regeneration. In the last decade, satellite cells have become one of the most studied adult stem cell systems and have emerged as a standard model not only in the field of stem cell-driven tissue regeneration but also in stem cell dysfunction and aging. Here, we provide background in the field and discuss recent advances in our understanding of muscle stem cell function and dysfunction, particularly in the case of aging, and the potential involvement of muscle stem cells in genetic diseases such as the muscular dystrophies.read more
Citations
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Proteostatic and Metabolic Control of Stemness
Laura García-Prat,Laura García-Prat,Pedro Sousa-Victor,Pura Muñoz-Cánoves,Pura Muñoz-Cánoves +4 more
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Autophagy and the hallmarks of aging.
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Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease
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A real-time monitoring platform of myogenesis regulators using double fluorescent labeling
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The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
Bertal H. Aktas,Bertal H. Aktas,Berin Upcin,Erik Henke,Manju Padmasekar,Xuebin Qin,Süleyman Ergün +6 more
TL;DR: Cellular networks used by various stem cells for generation and maintenance of a pristine proteome are summarized and the coordination of these networks with one another and their integration with the gene regulatory and signaling networks are explored.
References
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Patrick Seale,Luc A. Sabourin,Adele Girgis-Gabardo,Ahmed Mansouri,Peter Gruss,Michael A. Rudnicki +5 more
TL;DR: The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts and it was demonstrated that satellite cells and muscle-derived stem cells represent distinct cell populations.
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