Journal ArticleDOI
Autophagy and the hallmarks of aging.
Susmita Kaushik,Inmaculada Tasset,Esperanza Arias,Olatz Pampliega,Esther Wong,Marta Martinez-Vicente,Ana Maria Cuervo +6 more
TLDR
In this paper, the authors summarize evidence for the contribution of autophagy to health and lifespan and provide examples of the bidirectional interplay between autophagic pathways and several of the so-called hallmarks of aging.About:
This article is published in Ageing Research Reviews.The article was published on 2021-09-24. It has received 59 citations till now. The article focuses on the topics: Proteostasis & Autophagy.read more
Citations
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Journal ArticleDOI
The different autophagy degradation pathways and neurodegeneration
Angeleen Fleming,Mathieu Bourdenx,M Fujimaki,Cansu Karabiyik,Gregory J. Krause,Ana Lopez,Adrián Martín-Segura,Claudia Puri,Aurora Scrivo,John Skidmore,Sung Min Son,Eleanna Stamatakou,Lidia Wrobel,Ye Zhu,Ana Maria Cuervo,David C. Rubinsztein +15 more
TL;DR: The term autophagy encompasses different pathways that route cytoplasmic material to lysosomes for degradation and includes macroautophagy, chaperone-mediated autophathy, and microautophathy as discussed by the authors .
Journal ArticleDOI
Autophagy in health and disease: From molecular mechanisms to therapeutic target
TL;DR: This review will focus on the latest development of autophagy research, covering molecular mechanisms in control of autphagosome biogenesis and autophagosome–lysosome fusion, and the upstream regulatory pathways including the AMPK and MTORC1 pathways.
Journal ArticleDOI
Autophagy and Renal Fibrosis
TL;DR: In this article , the authors describe the characteristics of autophagy and summarize the recent advances in understanding the functions of auto-phagia in renal fibrosis, and discuss the possibility of using autophagia as a potential therapeutic target for renal disease.
Journal ArticleDOI
Macrophage autophagy in macrophage polarization, chronic inflammation and organ fibrosis
TL;DR: The current understanding of the function of macrophages autophagy in macrophage polarization, chronic inflammation, and organ fibrosis in different organs is reviewed, and the potential role of macophage autophagic in the treatment of fibrosis is highlighted.
Journal ArticleDOI
Aging conundrum: A perspective for ovarian aging
TL;DR: The hallmarks of aging are discussed and the potential role of stem cells and cryopreservation of embryos, oocytes, or ovarian tissue in the delay of ovarian aging is elaborated.
References
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Journal ArticleDOI
The Hallmarks of Aging
TL;DR: Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects.
Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu,Satoshi Waguri,Satoshi Waguri,Tomoki Chiba,Shigeo Murata,Junichi Iwata,Junichi Iwata,Isei Tanida,Takashi Ueno,Masato Koike,Yasuo Uchiyama,Eiki Kominami,Keiji Tanaka +12 more
TL;DR: It is found that mice lacking Atg7 specifically in the central nervous system showed behavioural defects, including abnormal limb-clasping reflexes and a reduction in coordinated movement, and died within 28 weeks of birth, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies.
Journal ArticleDOI
Autophagy regulates lipid metabolism
Rajat Singh,Susmita Kaushik,Yongjun Wang,Youqing Xiang,Inna Novak,Masaaki Komatsu,Keiji Tanaka,Ana Maria Cuervo,Mark J. Czaja +8 more
TL;DR: A previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy) is identified that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.
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Autophagy for the avoidance of degenerative, inflammatory, infectious, and neoplastic disease.
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