Mutations and Chromosomal Rearrangements Affecting the Expression of Snail, a Gene Involved in Embryonic Patterning in DROSOPHILA MELANOGASTER.
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TLDR
It is concluded that the products of all of these genes function together in the process of specification of pattern in the embryo.Abstract:
Mutants at the snail locus are zygotically acting embryonic lethals that affect dorsoventral patterning. A comparison of seven mutant alleles shows considerable variation in expressivity and a graded effect along the dorsoventral axis: more extreme alleles result in the abnormal development of the dorsally derived ectoderm as well as the ventrally derived mesoderm, whereas weaker alleles affect only development of the mesoderm. Animals transheterozygous for different mutant alleles occasionally survive to adulthood; they frequently have missing halteres and more rarely are hemithorax. The mutant phenotype of snail is shown here to be enhanced zygotically by haploidy of two nearby regions on the second chromosome: the elbow to no-ocelli region and the interval defined by l(2)br36 and l(2)br37. It is concluded that the products of all of these genes function together in the process of specification of pattern in the embryo.read more
Citations
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Journal ArticleDOI
The snail superfamily of zinc-finger transcription factors.
TL;DR: The Snail superfamily of zinc-finger transcription factors is involved in processes that imply pronounced cell movements, both during embryonic development and in the acquisition of invasive and migratory properties during tumour progression.
Journal ArticleDOI
The Role of Snail in EMT and Tumorigenesis.
TL;DR: Emerging evidences indicate that Snail causes a metabolic reprogramming, bestows tumor cells with cancer stem cell-like traits, and additionally, promotes drug resistance, tumor recurrence and metastasis.
Journal Article
The transcriptional repressor Snail promotes mammary tumor recurrence
Susan E. Moody,Denise Perez,Tien-chi Pan,Christopher J. Sarkisian,Carla P. Portocarrero,Christopher J. Sterner,Kathleen L. Notorfrancesco,Robert D. Cardiff,Lewis A. Chodosh +8 more
TL;DR: This article showed that the transcriptional repressor Snail is spontaneously upregulated in recurrent tumors in vivo and that recurrence is accompanied by epithelial-to-mesenchymal transition (EMT).
Journal ArticleDOI
Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail
TL;DR: EMT was associated with the simultaneous repression of the genes encoding E-cadherin and claudins/occludin (i.e. the expression of adherens and tight junction adhesion molecules, respectively).
Journal ArticleDOI
The transcriptional repressor Snail promotes mammary tumor recurrence
Susan E. Moody,Denise Perez,Tien-chi Pan,Christopher J. Sarkisian,Carla P. Portocarrero,Christopher J. Sterner,Kathleen L. Notorfrancesco,Robert D. Cardiff,Lewis A. Chodosh +8 more
TL;DR: It is demonstrated that the transcriptional repressor Snail is spontaneously upregulated in recurrent tumors in vivo and that recurrence is accompanied by epithelial-to-mesenchymal transition (EMT), consistent with a causal role for Snail in these processes.
References
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Book ChapterDOI
Maternal Effect Mutations that Alter the Spatial Coordinates of the Embryo of Drosophila melanogaste
Journal ArticleDOI
The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. IV: scutoid, an antimorphic mutation.
TL;DR: The simplest hypothesis is that Sco is a small reciprocal transposition, the genes noc, osp, and Adh exchanging places with three genes normally mapping proximal to them: l(2)br34, 1( 2)br35 and rd.
Journal ArticleDOI
Potentiometric microbiological assay of gentamicin, streptomycin, and neomycin with a carbon dioxide gas-sensing electrode.
D. L. Simpson,R. K. Kobos +1 more
Journal ArticleDOI
The genetics of a small autosomal region of drosophila melanogaster containing the structural gene for alcohol dehydrogenase. vi. induced revertants of scutoid
TL;DR: Twenty-six induced revertants of Scutoid (Sco), a dominant mutation of Drosophila melanogaster, have been characterized genetically and their properties suggest an interaction between the pu-noc and l(2)br28-l( 2)br37 regions of chromosome arm 2L and also demonstrate the genetic complexity of the el-nOC region.