Myeloid-derived suppressor cells as regulators of the immune system.
TLDR
The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.Abstract:
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.read more
Citations
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Alternative Activation of Macrophages: Mechanism and Functions
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References
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
TL;DR: A phenotypical and functional analysis of several surface molecules previously suggested to be involved in MDSC-mediated suppression of T cells indicate that suppressive features of M DSC is caused not by expansion of a specific subset but more likely represent a functional state of these cells.
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Regulation of immune responses by L-arginine metabolism.
Vincenzo Bronte,Paola Zanovello +1 more
TL;DR: This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions.
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The role of myeloid cells in the promotion of tumour angiogenesis
TL;DR: The therapeutic implications of recent findings that specific myeloid cell populations modulate the responses of tumours to agents such as chemotherapy and some anti-angiogenic therapies are discussed.
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Reactive oxygen species: role in the development of cancer and various chronic conditions
Gulam Waris,Haseeb Ahsan +1 more
TL;DR: Elevated levels of ROS and down regulation of ROS scavengers and antioxidant enzymes are associated with various human diseases including various cancers, also implicated in diabtes and neurodegenerative diseases.