Journal ArticleDOI
N-methyl-D-aspartate receptor binding in brains of rats at different ages
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TLDR
The lack of senescence-related differences in these biochemical markers does not preclude the possibility of functional changes in the NMDA receptor with aging.About:
This article is published in Neurobiology of Aging.The article was published on 1997-05-01. It has received 26 citations till now. The article focuses on the topics: Dizocilpine & NMDA receptor.read more
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Impact of aging on hippocampal function: plasticity, network dynamics, and cognition.
TL;DR: Studies of the effects of aging on hippocampal anatomy, physiology, plasticity, and network dynamics may lead to a better understanding of age-related cognitive deficits, including deficits in the induction and maintenance of long-term potentiation and lower thresholds for depotentiation and long- term depression.
Journal ArticleDOI
β-Amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis
Tibor Harkany,István M. Ábrahám,W Timmerman,Gábor Laskay,B. Tóth,Mária Sasvári,Csaba Kónya,JB Sebens,Jakob Korf,Csaba Nyakas,Marta Zarandi,Katalin Soós,Botond Penke,P.G.M. Luiten +13 more
TL;DR: In this article, the authors report correlative in vitro and in vivo evidence that an excitotoxic cascade mediates Abeta neurotoxicity in the rat magnocellular nucleus basalis (MBN).
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Age-related impairment in long-term potentiation in hippocampus: a role for the cytokine, interleukin-1 beta?
TL;DR: The evidence which suggests that age-related changes in membrane composition, triggered by oxidative changes, might significantly contribute to the impairment in LTP, is considered and the hypothesis that interleukin-1 beta plays a significant role in ageing in the hippocampus is proposed.
Journal ArticleDOI
Growth hormone, insulin-like growth factor-1 and the aging brain
TL;DR: This review is intended to highlight the effects of the GH and IGF-1 on neuronal structure, function, and plasticity and address several potential mechanisms through which the age-related reductions in GH andIGF-1 affect cognition.
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Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats.
William E. Sonntag,S. A. Bennett,Amir S. Khan,Phillip L. Thornton,Xiaowei Xu,Rhonda L. Ingram,Judy K. Brunso-Bechtold +6 more
TL;DR: It is concluded that both age and IGF-1 regulate the expression of NMDA receptor subtypes and suggest that age-related changes inNMDA receptor heterogeneity may result in functional changes in the receptor that have relevance for aging.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
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Ligand: a versatile computerized approach for characterization of ligand-binding systems.
Peter J. Munson,David Rodbard +1 more
TL;DR: This approach provides two major advantages compared with other available methods: it uses an exact mathematical model of the ligand-binding system, thereby avoiding the possible biases introduced by several commonly used approximations and it uses a statistically valid, appropriately weighted least-squares curve-fitting algorithm with objective measurement of goodness of fit.
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Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
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Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5
TL;DR: This article showed that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning.
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Glycine potentiates the NMDA response in cultured mouse brain neurons
J. W. Johnson,P Ascher +1 more
TL;DR: G glycine may facilitate excitatory transmission in the brain through an allosteric activation of the NMDA receptor, and can be observed in outside-out patches as an increase in the frequency of opening of the channels activated by NMDA agonists.