Showing papers in "Neurobiology of Aging in 1997"

TL;DR: The arithmetic means of the stages of both the amyloid-depositing and the neurofibrillary pathology increase with age, and age is a risk factor for Alzheimer's disease.

TL;DR: The consensus recommendations for improving the neuropathological criteria for the postmortem diagnosis of Alzheimer's disease are reported here, and the "position papers" by members of the Working Group that accompany this report elaborate on the research findings and concepts upon which these recommendations were based.

TL;DR: Evidence is observed for quantitative progression of neurofibrillary pathology in advanced cases of AD clearly meeting criteria for stages V and VI and the importance of categorizing classical and primitive plaques with respect to their PHF immunoreactivity has been demonstrated.

TL;DR: The cross-sectional data suggest that, within the temporal lobe, specific hippocampal volume reductions separated the group at risk for DAT from the normal group, and the fusiform gyrus volume uniquely improved the ability of the hippocampusal volume to separate MCI from DAT individuals.

TL;DR: Results demonstrate increased lipid peroxidation in AD brain and suggest a role for 4-HNE in the neurodegenerative process.

TL;DR: Application of advanced silver techniques to demonstrate Alzheimer's disease-related lesions allows recognition of the hallmarks of other disorders, such as Lewy body disease (Parkinson's disease) and dementia with argyrophilic grains, which frequently co-occur with dementia.

TL;DR: The results of the present study indicate that hippocampal formation atrophy is associated with memory and cognitive impairments and further longitudinal and neuropathologic work is required to validate the relationship between hippocampal Formation atrophy and AD.

TL;DR: It is concluded, that APLP2 and APP can substitute for each other functionally functionally in vivo and are required for early postnatal development.

TL;DR: The findings show that the atrophy of the human white matter during ageing is probably caused by a loss of myelinated fibers with a small diameter.

TL;DR: It is hypothesized that decreased expression of hippocampal mineralocorticoid receptors (MR) may account for the flattened diurnal cortisol secretory curve observed in PD patients, whereas the intact diurnal profile in AD patients may be due to a relative increase in MR compensating for the hippocampal neuronal loss commonly occurring in this disorder.

TL;DR: C5b-9 is abundantly present in Alzheimer's disease cortex, associated with neurofibrillary tangle containing neurons, dystrophic neurites within neuritic plaques, and neuropil threads, but is weakly detected, if at all, in nondemented elderly cortex under the same conditions.

TL;DR: The age-related increase in brain MAO B in living subjects is consistent with postmortem reports, but the degree of increase is generally lower.

TL;DR: The recommendation that diagnosis rest upon both neuritic plaque and neurofibrillary tangle frequency/distribution in the neocortex is worrisome, and it is recommended that neuropathology data available on autopsies of over 200 CERAD dementia subjects be used for testing potential modifications of the diagnostic algorithm.

TL;DR: It is concluded that the AD-related change in GLut-1 expression is not the result of altered poly(A) length of GLUT-1 mRNA.

TL;DR: A practical neuropathological approach to the diagnosis of AD requires both widespread neocortical SP and an advanced stage of neurofibrillary degeneration, and the rationale for adopting this conservative approach is that knowledge is incomplete with respect to fundamental differences between the lesions in aging and AD.

TL;DR: The relationship between the neurofibrillary tangles and the intellectual deficit observed in senile dementia of the Alzheimer type was studied and it was proposed that the presence of tangles in a given area is a more significant information than the value of their density.

TL;DR: The antisaccade eye movement task, which has been linked to frontal lobe function, presents a target in one visual field and asks subjects to move their eyes to the same location in the opposite field, to determine which functions are affected by aging.

TL;DR: Comparisons of presynaptic fiber potentials and non-N-methyl-D-aspartate and NMDAR-mediated synaptic responses in CA1 suggest that age-related functional alterations in neurotransmitter receptor subtypes occur differentially between closely-related anatomical subregions.

TL;DR: In a clinically demented patient without vascular or other neurodegenerative lesions, a clinico-pathologic diagnosis of AD can be made with a high level of confidence by demonstrating, and without counting, plaques and tangles.

TL;DR: In this article, the authors argue that neuropathological assessment should stand independently of clinical history and instead should describe brain lesions in the context of the topography and natural history of the disease.

TL;DR: The results suggest that the circuit-specific decrease in N-methyl-D-aspartate receptor subunit 1 reported previously occurs in the absence of structural compromise of the perforant path, and thus may be linked to an age-related change in the physiological properties of this circuit.

TL;DR: No clear age-related changes in MAO-A were observed, indicating an independent regulation of the two isoenzymes, also suggested by the cross-correlation analysis of these data.

TL;DR: As a group, aged monkeys were impaired on both the spatial and color conditions of the DRST, achieving about twothirds of the span of the young adult group in each condition.

TL;DR: The total number of the neuromelanin-containing neurons of the nucleus coeruleus was determined by means of a newly developed unbiased stereological counting scheme and a low-cost apparative set-up and there was no correlation between the age of the individuals and the cell number.

TL;DR: It is reported that there is an age-related increase in expression of IL-1 beta in hippocampus and it is proposed that this change may underlie the attenuated responses toIL-1 Beta in hippocampus of aged animals.

TL;DR: Findings show that selective age related atrophy of the corpus callosum differs in men and women late in life.

TL;DR: In this article, the authors studied the expression of three members of the Bcl-2 protein family, i.e., Bcl2, Bclx, and Bax, in a selection of senile and DS-related AD patients as well as in controls.

TL;DR: Two intriguing species differences in orangutans may provide clues to the mechanisms of amyloid deposition and the development of neuropathologic changes in AD.

TL;DR: The notion that peripheral glucoregulation can influence memory performance and that the ingestion of glucose can influence certain aspects of memory functioning is supported.