N-terminal proline-rich domain is required for scrambling activity of human phospholipid scramblases.
TLDR
It is concluded that scramblases exhibit Ca2+-dependent scrambling activity by aggregation of protein, and the results suggest that PRD is crucial for the function of the protein.About:
This article is published in Journal of Biological Chemistry.The article was published on 2014-05-09 and is currently open access. It has received 19 citations till now. The article focuses on the topics: Phospholipid scrambling & Phospholipid scramblase.read more
Citations
More filters
Journal ArticleDOI
Roles and regulation of phospholipid scramblases
TL;DR: The characterization of PL scramblase (PLSCR) and XKR family members and TMEM16 family members which contribute to phosphatidylserine exposure in response to apoptotic stimuli are described and their potential roles in pathogenic conditions are reported.
Journal ArticleDOI
Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication.
Weiyu Luo,Jie Zhang,Libin Liang,Guangwen Wang,Qibing Li,Pengyang Zhu,Yuan Zhou,Junping Li,Yuhui Zhao,Nan Sun,Shanyu Huang,Chenchen Zhou,Yu Chang,Pengfei Cui,Pucheng Chen,Yongping Jiang,Guohua Deng,Zhigao Bu,Chengjun Li,Li Jiang,Hualan Chen +20 more
TL;DR: It is found that the stable overexpression of PLSCR1 suppressed the nuclear import of NP, hindered the virus life cycle, and significantly inhibited the replication of various influenza subtypes.
Journal ArticleDOI
The role of human phospholipid scramblases in apoptosis: An overview.
TL;DR: The role of hPLSCRs in mediating cell death through phosphatidylserine exposure, interaction with death receptors, cardiolipin exposure, heavy metal and radiation induced apoptosis and pathological apoptosis followed by their involvement in cancer cells are discussed.
Journal ArticleDOI
Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
Jizheng Guo,Jie Li,Lin Xia,Yang Wang,Jinhang Zhu,Juan Du,Yungang Lu,Guodong Liu,Xiaoqiang Yao,Bing Shen +9 more
TL;DR: The present study suggested that TRPC5-PLSCR1 is a signaling complex mediating PS externalization and apoptosis in neurons and thatTRPC5 plays a pathological role in cerebral-ischemia reperfusion injury.
Journal ArticleDOI
Tubby-like protein superfamily member PLSCR3 functions as a negative regulator of adipogenesis in mouse 3T3-L1 preadipocytes by suppressing induction of late differentiation stage transcription factors.
TL;DR: F Forced overexpression of PLSCR3 in 3T3-L1 cells inhibited adipogenesis by suppressing induction of late stage pro-adipogenic transcription factors.
References
More filters
Journal ArticleDOI
Phospholipids in animal eukaryotic membranes: transverse asymmetry and movement.
Journal ArticleDOI
Calcium-dependent phospholipid scrambling by TMEM16F
TL;DR: It is shown that TMEM16F (transmembrane protein 16F) is an essential component for the Ca2+-dependent exposure of PtdSer on the cell surface, which results from a defect in phospholipid scrambling activity and is found to carry a mutation at a splice-acceptor site of the gene encoding TMEM 16F, causing the premature termination of the protein.
Journal ArticleDOI
GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery.
TL;DR: The pH-controlled membrane permealization induced by GALA and related peptides serve as a paradigm for the design of environmentally responsive peptidic delivery vehicles for drugs and genes.
Journal ArticleDOI
Pore formation and translocation of melittin
TL;DR: A novel model for the melittin pore formation was discussed in comparison with other pore-forming peptides, and a new double-labeling method clarified that the pore size increased with the peptide-to-lipid ratio.