Journal ArticleDOI
Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies.
Anjali Singh,Iqbal Ahmad,Sohail Akhter,Gaurav K. Jain,Zeenat Iqbal,Sushama Talegaonkar,Farhan Jalees Ahmad +6 more
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TLDR
Improved drug stability was further established by the subjection of the THQ-SLNs to accelerated stability studies (as per ICH guidelines) in contrast to the ThQ-suspension.About:
This article is published in Colloids and Surfaces B: Biointerfaces.The article was published on 2013-02-01. It has received 100 citations till now.read more
Citations
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Thymoquinone and its therapeutic potentials.
Sara Darakhshan,Sara Darakhshan,Ali Bidmeshki Pour,Abasalt Hosseinzadeh Colagar,Sajjad Sisakhtnezhad +4 more
TL;DR: Report on and analyze numerous properties of the active ingredient of N. sativa seeds, TQ, in the context of its therapeutic potentials for a wide range of illnesses and summarize the drug's possible mechanisms of action.
Journal ArticleDOI
Natural product-based nanomedicine: recent advances and issues
TL;DR: Recent progress is summarized in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications, including drug targeting and potential nanoparticle toxicity.
Journal ArticleDOI
Thymoquinone: fifty years of success in the battle against cancer models.
TL;DR: The current state of knowledge of TQ's adjuvant potential and in vivo antitumor activity is discussed and its ability to modulate the hallmarks of cancer is highlighted.
Journal ArticleDOI
Therapeutic Potential and Pharmaceutical Development of Thymoquinone: A Multitargeted Molecule of Natural Origin.
Sameer N. Goyal,Chaitali P. Prajapati,Prashant R. Gore,Chandragouda R. Patil,Umesh B Mahajan,Charu Sharma,Sandhya P. Talla,Shreesh Ojha +7 more
TL;DR: The present review aimed to provide insights regarding the physicochemical characteristics, pharmacokinetics and the methods to promote pharmaceutical development and endorse the clinical usage of TQ in future by overcoming the associated physiochemical obstacles.
Journal ArticleDOI
Aqueous solubility and degradation kinetics of the phytochemical anticancer thymoquinone; probing the effects of solvents, pH and light.
TL;DR: Overall, the current study concludes that TQ is unstable in aqueous solutions, particularly at an alkaline pH, in addition to presenting severe light sensitivity, which indicates the inappropriateness of aqueously solutions as pharmaceutical vehicles for TQ preparations.
References
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A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.
Stanley Reitman,Sam Frankel +1 more
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Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
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A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum
TL;DR: A rapid method has been devised which requires only 5 c.mm.
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Challenges and solutions for the delivery of biotech drugs--a review of drug nanocrystal technology and lipid nanoparticles.
TL;DR: The use of nanoparticulate carriers, developed in the research group, are described as one solution to overcome drug-associated delivery problems, i.e. drug nanocrystals, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and lipid-drug conjugate (LDC) nanoparticles.
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Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs
Gary Liversidge,Kenneth C. Cundy +1 more
TL;DR: In this paper, a randomized crossover study was conducted in fasted male beagle dogs to compare absolute oral bioavailability of danazol from three formulations, i.e., an aqueous dispersion of nanoparticulate Danazol (mean particle size 169 nm), B, danazOL-hydroxypropyl-β-cyclodextrin (HPB) complex, C, an aiquous suspension of conventional DanazOL particles (means particle size 10 μm).