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Journal ArticleDOI

Nanocrystallization: A Unique Approach to Yield Bright Organic Nanocrystals for Biological Applications

TLDR
A new bottom-up nanocrystallization method is developed to fabricate highly fluorescent organic nanocrystals in aqueous media using an aggregation-induced emission fluorogen (AIEgen) as an example.
Abstract
A new bottom-up nanocrystallization method is developed to fabricate highly fluorescent organic nanocrystals in aqueous media using an aggregation-induced emission fluorogen (AIEgen) as an example. The nanocrystallization strategy leads to the fabrication of uniform nanocrystals of 110 ± 10 nm size in aqueous media, which shows over 400% increase in brightness as compared to the amorphous nanoaggregates.

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Citations
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Journal ArticleDOI

Aggregation-Induced Emission (AIE) Dots: Emerging Theranostic Nanolights.

TL;DR: The recent advance of AIE dots is summarized and their great potential as theranostic nanolights in biomedical applications is highlighted, with particular interest is AIE photosensitizer dots, which simultaneously show bright fluorescence and high photosensitization, yielding superior performance to commercial photosensitized nanoparticles in image-guided therapy.
Journal ArticleDOI

Enhancing the performance of pure organic room-temperature phosphorescent luminophores

TL;DR: This Review discusses the fundamental mechanism of RTP in pure organic Luminophores, followed by design principles, enhancement strategies, and formulation methods to achieve highly phosphorescent and long-lived organic RTP luminophores even in aqueous media.
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Organic Nanocrystals with Bright Red Persistent Room-Temperature Phosphorescence for Biological Applications.

TL;DR: A new design strategy for realizing high brightness and long lifetime of red-emissive RTP molecules is reported, which is based on introducing an alkoxy spacer between the hybrid units in the molecule.
Journal ArticleDOI

Design of superior phototheranostic agents guided by Jablonski diagrams

TL;DR: This review summarizes the recent progress of organic phototheranostic agents with an emphasis on the main strategies to manipulate the three excitation energy dissipation pathways, namely, radiative decay, thermal deactivation, and intersystem crossing, with the assistance of a Jablonski diagram.
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Precise Molecular Design for High-Performance Luminogens with Aggregation-Induced Emission

TL;DR: The useful principles and emerging structure–property relationships for precise molecular design toward AIEgens with desirable properties using concrete examples are revealed and their excellent performance in enabling new research directions in biomedical theranostics, optoelectronic devices, stimuli‐responsive smart materials, and visualization of physical processes are highlighted.
References
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Journal ArticleDOI

Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole

TL;DR: Aggregation greatly boosts emission efficiency of the silole, turning it from a weak luminophor into a strong emitter.
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Aggregation-Induced Emission: Together We Shine, United We Soar!

TL;DR: This paper presents a meta-analysis of the chiral stationary phase transition of Na6(CO3)(SO4)2, a major component of the response of the immune system to Na2CO3.
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.

TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Rate of Nucleation in Condensed Systems

TL;DR: On the basis of the nucleation theory developed by Volmer, Becker, and co-workers, and the theory of absolute reaction rates, an expression for the absolute rate of nucleation in condensed systems was derived in this paper.
Journal ArticleDOI

Bioprobes Based on AIE Fluorogens

TL;DR: The simple design and fluorescenceturn-on feature of the molecular AIE bioprobes offer direct visualization of specific analytes and biological processes in aqueous media with higher sensitivity and better accuracy than traditional fluorescence turn-off probes.
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