Nanotechnology-based drug delivery systems and herbal medicines: a review.
Bruna Vidal Bonifácio,Patrícia Bento da Silva,Matheus Aparecido dos Santos Ramos,Kamila Maria Silveira Negri,Taís Maria Bauab,Marlus Chorilli +5 more
TLDR
Nanotechnology-based drug delivery systems and herbal medicines are reviewed to see if nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity.Abstract:
Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.read more
Citations
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Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
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Natural product-based nanomedicine: recent advances and issues
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Metal nanoparticles fabricated by green chemistry using natural extracts: biosynthesis, mechanisms, and applications
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Update on Monoterpenes as Antimicrobial Agents: A Particular Focus on p-Cymene.
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TL;DR: This review summarizes available scientific data, as reported by the most recent studies describing the antimicrobial activity of p-cymene either alone, or as the main component of plant extracts, as well as addressing the mechanisms of action of cymenes as antimicrobial agents.
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Nanotechnology-based drug delivery systems for control of microbial biofilms: a review.
Matheus Aparecido dos Santos Ramos,Patrícia Bento da Silva,Larissa Spósito,Luciani Gaspar de Toledo,Bruna Vidal Bonifácio,Camila Fernanda Rodero,Karen Cristina dos Santos,Marlus Chorilli,Taís Maria Bauab +8 more
TL;DR: The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticle, polymeric nanop articles, and metallic nanoparticles; in controlling microbial biofilms by targeted drug delivery.
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