Journal ArticleDOI
Naphthalene Derivatives and Quinones from Ventilago denticulata and Their Nitric Oxide Radical Scavenging, Antioxidant, Cytotoxic, Antibacterial, and Phosphodiesterase Inhibitory Activities.
Wannapha Molee,Wannapha Molee,Anuchit Phanumartwiwath,Chatchai Kesornpun,Sanya Sureram,Nattaya Ngamrojanavanich,Kornkanok Ingkaninan,Chulabhorn Mahidol,Chulabhorn Mahidol,Somsak Ruchirawat,Somsak Ruchirawat,Prasat Kittakoop,Prasat Kittakoop +12 more
TLDR
New naphthalene derivatives and a new isomer of ventilagolin, together with known anthraquinones, chrysophanol, physcion or emodin 3‐methyl ether, andEmodin, were isolated from vines of Ventilago denticulata and exhibited cytotoxic activity and weak antibacterial activity.Abstract:
New naphthalene derivatives (1 and 2) and a new isomer (3) of ventilagolin, together with known anthraquinones, chrysophanol (4), physcion or emodin 3-methyl ether (5), and emodin (6), were isolated from vines of Ventilago denticulata. The isolated compounds exhibited cytotoxic activity with IC50 values of 1.15 - 40.54 μg/ml. Compounds 1 - 3 selectively exhibited weak antibacterial activity (MIC values of 200.0 - 400.0 μg/ml), while emodin (6) displayed moderate antibacterial activity with MIC value of 25.0 μg/ml. The isolated compounds showed nitric oxide and DPPH radical scavenging activities. Compounds 1 - 3 and 6 exhibited weak xanthine oxidase inhibitory activity, while emodin (6) acted as an aromatase inhibitor with the IC50 value of 10.1 μm. Compounds 1 and 2 exhibited phosphodiesterase 5 inhibitory activity with IC50 values of 8.28 μm and 6.48 μm, respectively.read more
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Journal ArticleDOI
Physcion and physcion 8-O-β-glucopyranoside: A review of their pharmacology, toxicities and pharmacokinetics.
XunLi,Ying-Jiao Liu,Shifeng Chu,Songwei Yang,Ye Peng,Siyu Ren,Bi-Rui Wen,Nai-Hong Chen,Nai-Hong Chen +8 more
TL;DR: The aim of present review is to give a comprehensive summary and analysis of the pharmacology, toxicity and pharmacokinetics of physcion and PG by consulting all the currently available literatures published in PubMed then give a future prospects about it.
Journal ArticleDOI
UHPLC-ESI-QTOF-MS/MS-Based Molecular Networking Guided Isolation and Dereplication of Antibacterial and Antifungal Constituents of Ventilago denticulata.
Muhaiminatul Azizah,Patcharee Pripdeevech,Tawatchai Thongkongkaew,Chulabhorn Mahidol,Chulabhorn Mahidol,Somsak Ruchirawat,Somsak Ruchirawat,Prasat Kittakoop,Prasat Kittakoop +8 more
TL;DR: UHPLC-ESI-QTOF-MS/MS-Based molecular networking guided isolation and dereplication led to the identification of antibacterial and antifungal agents in V. denticulata, an herbal medicine for the treatment of wound infection that may rich in antibacterial agents.
Journal ArticleDOI
Emodin protects hyperglycemia-induced injury in PC-12 cells by up-regulation of miR-9
TL;DR: Emodin protected PC-12 cells against high glucose-induced apoptosis and autophagy, and the neuroprotective activities might be realized by up-regulation of miR-9, and modulation of PI3K/AKT and NF-κB signaling pathways.
Journal ArticleDOI
Pyranonaphthoquinone and anthraquinone derivatives from Ventilago harmandiana and their potent anti-inflammatory activity.
Kanda Panthong,Sakchai Hongthong,Chutima Kuhakarn,Pawinee Piyachaturawat,Kanoknetr Suksen,Ampai Panthong,Natthakarn Chiranthanut,Palangpon Kongsaeree,Samran Prabpai,Narong Nuntasaen,Vichai Reutrakul +10 more
TL;DR: The chemical study on the heartwoods extract of Ventilago harmandiana (Rhamnaceae) resulted in the isolation of ten previously undescribed pyranonaphthoquinones (ventilanones A-J), an undescribing anthraquinone (ventilone K), together with eight known anthraquone derivatives.
References
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Evaluation of a Tetrazolium-based Semiautomated Colorimetric Assay: Assessment of Radiosensitivity
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Aromatase Inhibitors in the Treatment of Breast Cancer
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Mechanism-based in vitro screening of potential cancer chemopreventive agents
Clarissa Gerhäuser,Karin Klimo,Elke H. Heiss,Isabell Neumann,Amira M. Gamal-Eldeen,Jutta Knauft,Guang-Yaw Liu,Somkid Sitthimonchai,Norbert Frank +8 more
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Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease
TL;DR: The effects of roflumilast on lung function and exacerbations, glucose homoeostasis and weight loss, and the concomitant use of long‐acting beta2‐adrenergic receptor agonists and short‐acting muscarinic receptor antagonists are provided.